Homo sapiens Gene: MGST2
Summary
InnateDB Gene IDBG-38573.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MGST2
Gene Name microsomal glutathione S-transferase 2
Synonyms GST2; MGST-II;
Species Homo sapiens
Ensembl Gene ENSG00000085871
Encoded Proteins
microsomal glutathione S-transferase 2
microsomal glutathione S-transferase 2
microsomal glutathione S-transferase 2
microsomal glutathione S-transferase 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family consists of six human proteins, several of which are involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation. This gene encodes a protein which catalyzes the conjugation of leukotriene A4 and reduced glutathione to produce leukotriene C4. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Feb 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:139665768-139740745
Strand Forward strand
Band q31.1
Transcripts
ENST00000265498 ENSP00000265498
ENST00000506797 ENSP00000424278
ENST00000515137
ENST00000502587
ENST00000503816 ENSP00000423008
ENST00000515067
ENST00000616265 ENSP00000482639
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004364 glutathione transferase activity
GO:0004464 leukotriene-C4 synthase activity
GO:0004602 glutathione peroxidase activity
GO:0008047 enzyme activator activity
Biological Process
GO:0006750 glutathione biosynthetic process
GO:0006805 xenobiotic metabolic process
GO:0010243 response to organonitrogen compound
GO:0019370 leukotriene biosynthetic process
GO:0032496 response to lipopolysaccharide
GO:0043085 positive regulation of catalytic activity
GO:0044281 small molecule metabolic process
GO:0055114 oxidation-reduction process
GO:1901687 glutathione derivative biosynthetic process
Cellular Component
GO:0005635 nuclear envelope
GO:0005737 cytoplasm
GO:0005789 endoplasmic reticulum membrane
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
GO:0043231 intracellular membrane-bounded organelle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Glutathione conjugation pathway
Aflatoxin activation and detoxification pathway
Phase II conjugation pathway
Metabolism pathway
Biological oxidations pathway
KEGG
Glutathione metabolism pathway
Metabolism of xenobiotics by cytochrome P450 pathway
Drug metabolism pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.662984
RefSeq NM_001204366 NM_001204367 NM_001204368 NM_002413
HUGO
OMIM
CCDS CCDS3749 CCDS56339
HPRD 03436
IMGT
EMBL
GenPept
RNA Seq Atlas