InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MGST2

Summary

InnateDB Protein

IDBP-482315.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MGST2

Protein Name

microsomal glutathione S-transferase 2

Synonyms

GST2; MGST-II;

Species

Homo sapiens

Ensembl Protein

ENSP00000423008

InnateDB Gene

IDBG-38573 (MGST2)

Protein Structure

UniProt Annotation

Function

Can catalyze the production of LTC4 from LTA4 and reduced glutathione. Can catalyze the conjugation of 1-chloro-2,4- dinitrobenzene with reduced glutathione.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Microsome membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Liver, spleen, skeletal muscle, heart, adrenals, pancreas, prostate, testis, fetal liver, and fetal spleen. Very low expression in lung, brain, placenta and bone marrow.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004364	glutathione transferase activity
GO:0004464	leukotriene-C4 synthase activity
GO:0004602	glutathione peroxidase activity
GO:0008047	enzyme activator activity

Biological Process

GO:0006750	glutathione biosynthetic process
GO:0006805	xenobiotic metabolic process
GO:0019370	leukotriene biosynthetic process
GO:0043085	positive regulation of catalytic activity
GO:0044281	small molecule metabolic process
GO:0055114	oxidation-reduction process
GO:1901687	glutathione derivative biosynthetic process

Cellular Component

GO:0005635	nuclear envelope
GO:0005789	endoplasmic reticulum membrane
GO:0005886	plasma membrane
GO:0016021	integral component of membrane
GO:0043231	intracellular membrane-bounded organelle