Version 5.4
Homo sapiens Gene: HIPK3
Summary
InnateDB Gene IDBG-38629.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HIPK3
Gene Name homeodomain interacting protein kinase 3
Synonyms DYRK6; FIST3; PKY; YAK1
Species Homo sapiens
Ensembl Gene ENSG00000110422
Encoded Proteins
IDBP-38631
homeodomain interacting protein kinase 3
IDBP-38633
homeodomain interacting protein kinase 3
IDBP-370841
homeodomain interacting protein kinase 3
IDBP-586652
homeodomain interacting protein kinase 3
IDBP-599499
homeodomain interacting protein kinase 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 11:33256672-33357023
Strand Forward strand
Band p13
Transcripts
ENST00000379016 ENSP00000368301
ENST00000303296 ENSP00000304226
ENST00000456517 ENSP00000398241
ENST00000525975 ENSP00000431710
ENST00000531504 ENSP00000433594
ENST00000534262
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 46 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 46 [view]
Protein-Protein 46 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0016773 phosphotransferase activity, alcohol group as acceptor
Biological Process
GO:0006355 regulation of transcription, DNA-templated
GO:0006468 protein phosphorylation
GO:0006915 apoptotic process
GO:0009103 lipopolysaccharide biosynthetic process
GO:0009299 mRNA transcription
GO:0018105 peptidyl-serine phosphorylation
GO:0018107 peptidyl-threonine phosphorylation
GO:0043066 negative regulation of apoptotic process
GO:0043508 negative regulation of JUN kinase activity
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0016020 membrane
GO:0016605 PML body
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000027177
View Gene Order
ENSBTAG00000014884
Not yet available
Pathways
NETPATH
NetPath_2
AndrogenReceptor pathway
NetPath_4
EGFR1 pathway
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.201918
RefSeq NM_001048200 NM_001278162 NM_001278163 NM_005734 XM_005252729 XM_006718120
HUGO
OMIM
CCDS CCDS41634 CCDS7884
HPRD 05111
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca