Homo sapiens Gene: PHF7
Summary
InnateDB Gene IDBG-38868.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PHF7
Gene Name PHD finger protein 7
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000010318
Encoded Proteins
PHD finger protein 7
PHD finger protein 7
PHD finger protein 7
PHD finger protein 7
PHD finger protein 7
PHD finger protein 7
PHD finger protein 7
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Spermatogenesis is a complex process regulated by extracellular and intracellular factors as well as cellular interactions among interstitial cells of the testis, Sertoli cells, and germ cells. In the testis, this gene is expressed in Sertoli cells but not germ cells. However, this gene is not expressed in a patient who exhibited spermatogenic arrest at the spermatocyte stage. Spermatogenic arrest is an interruption of germ cell differentiation that may result in oligospermia or azoospermia. The proteins encoded by this gene contain plant homeodomain (PHD) finger domains, also known as leukemia associated protein (LAP) domains, believed to be involved in transcriptional regulation. Thus this protein, which localizes to the nucleus of transfected cells, has been implicated in the transcriptional regulation of spermatogenesis. Two protein isoforms are encoded by transcript variants of this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:52410561-52423641
Strand Forward strand
Band p21.1
Transcripts
ENST00000327906 ENSP00000333024
ENST00000347025 ENSP00000246282
ENST00000473145
ENST00000482327
ENST00000472337
ENST00000461861 ENSP00000417712
ENST00000498509
ENST00000465863 ENSP00000420521
ENST00000459935
ENST00000614886 ENSP00000480003
ENST00000620464 ENSP00000478693
ENST00000615126 ENSP00000483724
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
Experimentally validated
Total 18 [view]
Protein-Protein 18 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008270 zinc ion binding
Biological Process
Cellular Component
GO:0005634 nucleus
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.372719
RefSeq NM_001278221 NM_016483 XM_005265225 XM_005265226 XM_005265227
HUGO
OMIM
CCDS CCDS2854 CCDS2855
HPRD 15127
IMGT
EMBL
GenPept
RNA Seq Atlas