Version 5.4
Homo sapiens Gene: CSF2RA
Summary
InnateDB Gene IDBG-39400.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CSF2RA
Gene Name colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)
Synonyms CD116; CDw116; CSF2R; CSF2RAX; CSF2RAY; CSF2RX; CSF2RY; GM-CSF-R-alpha; GMCSFR; GMR; SMDP4
Species Homo sapiens
Ensembl Gene ENSG00000198223
Encoded Proteins
IDBP-39402
colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)
IDBP-39404
colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)
IDBP-39408
colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)
IDBP-39412
colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)
IDBP-39414
colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)
IDBP-39418
colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)
IDBP-360985
colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)
IDBP-360993
colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)
IDBP-360995
colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)
IDBP-360999
colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)
IDBP-807112
colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)
IDBP-596692
colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)
IDBP-603926
colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is the alpha subunit of the heterodimeric receptor for colony stimulating factor 2, a cytokine which controls the production, differentiation, and function of granulocytes and macrophages. The encoded protein is a member of the cytokine family of receptors. This gene is found in the pseudoautosomal region (PAR) of the X and Y chromosomes. Multiple transcript variants encoding different isoforms have been found for this gene, with some of the isoforms being membrane-bound and others being soluble. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome X:1268800-1310381
Strand Forward strand
Band p22.33
Transcripts
ENST00000381529 ENSP00000370940
ENST00000381524 ENSP00000370935
ENST00000355432 ENSP00000347606
ENST00000355805 ENSP00000348058
ENST00000381509 ENSP00000370920
ENST00000381500 ENSP00000370911
ENST00000417535 ENSP00000394227
ENST00000432318 ENSP00000416437
ENST00000412290 ENSP00000410667
ENST00000419094 ENSP00000397452
ENST00000493312
ENST00000494969 ENSP00000476684
ENST00000481245
ENST00000486791 ENSP00000436825
ENST00000477940
ENST00000478256
ENST00000475259
ENST00000491683
ENST00000498153
ENST00000501036 ENSP00000440491
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
Experimentally validated
Total 12 [view]
Protein-Protein 12 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004872 receptor activity
GO:0004896 cytokine receptor activity
GO:0005515 protein binding
Biological Process
GO:0019221 cytokine-mediated signaling pathway
GO:0045471 response to ethanol
Cellular Component
GO:0005576 extracellular region
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
REACT_23891
Interleukin receptor SHC signaling pathway
REACT_23837
Interleukin-3, 5 and GM-CSF signaling pathway
REACT_27283
Interleukin-2 signaling pathway
REACT_1695
GPVI-mediated activation cascade pathway
REACT_19290
G beta:gamma signalling through PI3Kgamma pathway
REACT_75790
Cytokine Signaling in Immune system pathway
REACT_14797
Signaling by GPCR pathway
REACT_798
Platelet activation, signaling and aggregation pathway
REACT_19388
G-protein beta:gamma signalling pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_6900
Immune System pathway
REACT_22232
Signaling by Interleukins pathway
REACT_604
Hemostasis pathway
KEGG
hsa04640
Hematopoietic cell lineage pathway
hsa04060
Cytokine-cytokine receptor interaction pathway
hsa04630
Jak-STAT signaling pathway pathway
hsa05200
Pathways in cancer pathway
INOH
INOH website
JAK STAT pathway and regulation pathway
PID NCI
integrin_a9b1_pathway
Alpha9 beta1 integrin signaling events
gmcsf_pathway
GMCSF-mediated signaling events
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.520937
RefSeq NM_001161529 NM_001161530 NM_001161531 NM_001161532 NM_006140 NM_172245 NM_172246 NM_172247 NM_172249 XM_006724438 XM_006724440 XM_006724859 XM_006724861
HUGO
OMIM
CCDS CCDS35190 CCDS35191 CCDS35192 CCDS35193 CCDS55359 CCDS55360 CCDS55361
HPRD 02381
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca