Homo sapiens Gene: IL3RA | |||||||||||||||||||
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Summary | |||||||||||||||||||
InnateDB Gene | IDBG-39718.6 | ||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
Gene Symbol | IL3RA | ||||||||||||||||||
Gene Name | interleukin 3 receptor, alpha (low affinity) | ||||||||||||||||||
Synonyms | CD123; hIL-3Ra; IL3R; IL3RAY; IL3RX; IL3RY; | ||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||
Ensembl Gene | ENSG00000185291 | ||||||||||||||||||
Encoded Proteins |
interleukin 3 receptor, alpha (low affinity)
interleukin 3 receptor, alpha (low affinity)
interleukin 3 receptor, alpha (low affinity)
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Protein Structure | |||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
Entrez Gene | |||||||||||||||||||
Summary |
The protein encoded by this gene is an interleukin 3 specific subunit of a heterodimeric cytokine receptor. The receptor is comprised of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL3 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL3. This gene and the gene encoding the colony stimulating factor 2 receptor alpha chain (CSF2RA) form a cytokine receptor gene cluster in a X-Y pseudoautosomal region on chromosomes X or Y. Alternatively spliced transcript variants encoding distinct isoforms have been found. [provided by RefSeq, Jun 2012] |
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Gene Information | |||||||||||||||||||
Type | Protein coding | ||||||||||||||||||
Genomic Location | Chromosome X:1336616-1382689 | ||||||||||||||||||
Strand | Forward strand | ||||||||||||||||||
Band | p22.33 | ||||||||||||||||||
Transcripts |
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Interactions | |||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||
No orthologs found for this gene | |||||||||||||||||||
Pathways | |||||||||||||||||||
NETPATH |
IL3 pathway
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REACTOME |
Interleukin-3, 5 and GM-CSF signaling pathway
Cytokine Signaling in Immune system pathway
Signaling by GPCR pathway
Platelet activation, signaling and aggregation pathway
G-protein beta:gamma signalling pathway
Signal Transduction pathway
GPCR downstream signaling pathway
Immune System pathway
GPVI-mediated activation cascade pathway
Interleukin-2 signaling pathway
Interleukin receptor SHC signaling pathway
Signaling by Interleukins pathway
G beta:gamma signalling through PI3Kgamma pathway
Hemostasis pathway
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KEGG |
Cytokine-cytokine receptor interaction pathway
Apoptosis pathway
Jak-STAT signaling pathway pathway
Hematopoietic cell lineage pathway
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INOH |
IL-3 signaling pathway
JAK STAT pathway and regulation pathway
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PID BIOCARTA |
Il 3 signaling pathway
[Biocarta view]
Regulation of bad phosphorylation
[Biocarta view]
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PID NCI |
IL3-mediated signaling events
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Cross-References | |||||||||||||||||||
SwissProt | |||||||||||||||||||
TrEMBL | J3JS34 | ||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||
Entrez Gene | 3563 | ||||||||||||||||||
UniGene | Hs.632790 | ||||||||||||||||||
RefSeq | NM_002183 NM_001267713 XM_005274781 XM_005274432 XM_005274780 XM_005274431 | ||||||||||||||||||
HUGO | HGNC:6012 | ||||||||||||||||||
OMIM | 308385 430000 | ||||||||||||||||||
CCDS | CCDS14113 CCDS59158 | ||||||||||||||||||
HPRD | 08951 | ||||||||||||||||||
IMGT | |||||||||||||||||||
EMBL | AL683870 BX119906 BX901885 | ||||||||||||||||||
GenPept | |||||||||||||||||||
RNA Seq Atlas | 3563 | ||||||||||||||||||