InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: IL3RA

Summary

InnateDB Gene

IDBG-39718.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IL3RA

Gene Name

interleukin 3 receptor, alpha (low affinity)

Synonyms

CD123; hIL-3Ra; IL3R; IL3RAY; IL3RX; IL3RY;

Species

Homo sapiens

Ensembl Gene

ENSG00000185291

Encoded Proteins

IDBP-39720

interleukin 3 receptor, alpha (low affinity)

IDBP-39722

interleukin 3 receptor, alpha (low affinity)

IDBP-361022

interleukin 3 receptor, alpha (low affinity)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is an interleukin 3 specific subunit of a heterodimeric cytokine receptor. The receptor is comprised of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL3 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL3. This gene and the gene encoding the colony stimulating factor 2 receptor alpha chain (CSF2RA) form a cytokine receptor gene cluster in a X-Y pseudoautosomal region on chromosomes X or Y. Alternatively spliced transcript variants encoding distinct isoforms have been found. [provided by RefSeq, Jun 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:1336616-1382689

Strand

Forward strand

Band

p22.33

Transcripts

ENST00000331035	ENSP00000327890
ENST00000381469	ENSP00000370878
ENST00000432757	ENSP00000414867

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.

Experimentally validated
Total	25 [view]
Protein-Protein	24 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004896	cytokine receptor activity
GO:0004912	interleukin-3 receptor activity
GO:0005515	protein binding

Biological Process

GO:0019221	cytokine-mediated signaling pathway
GO:0036016	cellular response to interleukin-3
GO:0038156	interleukin-3-mediated signaling pathway
GO:0045087	innate immune response