Homo sapiens Gene: IL3RA
Summary
InnateDB Gene IDBG-39718.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IL3RA
Gene Name interleukin 3 receptor, alpha (low affinity)
Synonyms CD123; hIL-3Ra; IL3R; IL3RAY; IL3RX; IL3RY;
Species Homo sapiens
Ensembl Gene ENSG00000185291
Encoded Proteins
interleukin 3 receptor, alpha (low affinity)
interleukin 3 receptor, alpha (low affinity)
interleukin 3 receptor, alpha (low affinity)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is an interleukin 3 specific subunit of a heterodimeric cytokine receptor. The receptor is comprised of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL3 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL3. This gene and the gene encoding the colony stimulating factor 2 receptor alpha chain (CSF2RA) form a cytokine receptor gene cluster in a X-Y pseudoautosomal region on chromosomes X or Y. Alternatively spliced transcript variants encoding distinct isoforms have been found. [provided by RefSeq, Jun 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome X:1336616-1382689
Strand Forward strand
Band p22.33
Transcripts
ENST00000331035 ENSP00000327890
ENST00000381469 ENSP00000370878
ENST00000432757 ENSP00000414867
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
Experimentally validated
Total 25 [view]
Protein-Protein 24 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004896 cytokine receptor activity
GO:0004912 interleukin-3 receptor activity
GO:0005515 protein binding
Biological Process
GO:0019221 cytokine-mediated signaling pathway
GO:0036016 cellular response to interleukin-3
GO:0038156 interleukin-3-mediated signaling pathway
GO:0045087 innate immune response
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
No orthologs found for this gene
Pathways
NETPATH
IL3 pathway
REACTOME
Interleukin-3, 5 and GM-CSF signaling pathway
Cytokine Signaling in Immune system pathway
Signaling by GPCR pathway
Platelet activation, signaling and aggregation pathway
G-protein beta:gamma signalling pathway
Signal Transduction pathway
GPCR downstream signaling pathway
Immune System pathway
GPVI-mediated activation cascade pathway
Interleukin-2 signaling pathway
Interleukin receptor SHC signaling pathway
Signaling by Interleukins pathway
G beta:gamma signalling through PI3Kgamma pathway
Hemostasis pathway
KEGG
Cytokine-cytokine receptor interaction pathway
Apoptosis pathway
Jak-STAT signaling pathway pathway
Hematopoietic cell lineage pathway
INOH
IL-3 signaling pathway
JAK STAT pathway and regulation pathway
PID BIOCARTA
Il 3 signaling pathway [Biocarta view]
Regulation of bad phosphorylation [Biocarta view]
PID NCI
IL3-mediated signaling events
Cross-References
SwissProt
TrEMBL J3JS34
UniProt Splice Variant
Entrez Gene 3563
UniGene Hs.632790
RefSeq NM_002183 NM_001267713 XM_005274781 XM_005274432 XM_005274780 XM_005274431
HUGO HGNC:6012
OMIM 308385 430000
CCDS CCDS14113 CCDS59158
HPRD 08951
IMGT
EMBL AL683870 BX119906 BX901885
GenPept
RNA Seq Atlas 3563