InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: IL3RA

Summary

InnateDB Protein

IDBP-39722.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IL3RA

Protein Name

interleukin 3 receptor, alpha (low affinity)

Synonyms

CD123; hIL-3Ra; IL3R; IL3RAY; IL3RX; IL3RY;

Species

Homo sapiens

Ensembl Protein

ENSP00000370878

InnateDB Gene

IDBG-39718 (IL3RA)

Protein Structure

UniProt Annotation

Function

This is a receptor for interleukin-3.

Subcellular Localization

Membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.

Experimentally validated
Total	25 [view]
Protein-Protein	24 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004896	cytokine receptor activity
GO:0004912	interleukin-3 receptor activity
GO:0005515	protein binding

Biological Process

GO:0019221	cytokine-mediated signaling pathway
GO:0036016	cellular response to interleukin-3
GO:0038156	interleukin-3-mediated signaling pathway

Cellular Component

GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR003961 Fibronectin, type III
IPR015321 Interleukin-6 receptor alpha, binding

PFAM

PF00041
PF01108
PF09240

PRINTS

PIRSF

SMART

SM00060

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P26951

PhosphoSite

PhosphoSite-P26951

TrEMBL

J3JS34

UniProt Splice Variant

Entrez Gene

3563

UniGene

Hs.632790

RefSeq

NP_001254642

HUGO

HGNC:6012

OMIM

430000

CCDS

CCDS59158

HPRD

08951

IMGT

EMBL

AK290568 AL683870 AY789109 BC035407 BX119906 BX296563 BX901885 D49410 FJ550347 M74782

GenPept

AAA59148 AAH35407 AAV40832 ACM24116 BAA08393 BAF83257 CAI39694 CAI39695