Version 5.4
Homo sapiens Gene: ITIH3
Summary
InnateDB Gene IDBG-39731.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ITIH3
Gene Name inter-alpha-trypsin inhibitor heavy chain 3
Synonyms H3P
Species Homo sapiens
Ensembl Gene ENSG00000162267
Encoded Proteins
IDBP-379731
inter-alpha (globulin) inhibitor H3
IDBP-379732
inter-alpha (globulin) inhibitor H3
IDBP-806954
inter-alpha-trypsin inhibitor heavy chain 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The inter-alpha-trypsin inhibitors (ITI) are a family of structurally related plasma serine protease inhibitors involved in extracellular matrix stabilization and in prevention of tumor metastasis. The ITI family contains multiple proteins made up of a light chain (see MIM 176870) and a variable number of heavy chains (Salier et al., 1987 [PubMed 2446322]; Himmelfarb et al., 2004 [PubMed 14744536]).[supplied by OMIM, Nov 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:52794768-52809009
Strand Forward strand
Band p21.1
Transcripts
ENST00000449956 ENSP00000415769
ENST00000416872 ENSP00000413922
ENST00000467268
ENST00000465243
ENST00000463893
ENST00000464804
ENST00000465314
ENST00000475931
ENST00000495622
ENST00000493136
ENST00000621946 ENSP00000479928
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 2 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004866 endopeptidase inhibitor activity
GO:0004867 serine-type endopeptidase inhibitor activity
Biological Process
GO:0010951 negative regulation of endopeptidase activity
GO:0030212 hyaluronan metabolic process
Cellular Component
GO:0005576 extracellular region
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000006522
View Gene Order
ENSBTAG00000007846
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.76716
RefSeq NM_002217
HUGO
OMIM
CCDS CCDS46845
HPRD 00891
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca