Homo sapiens Gene: NSFL1C
Summary
InnateDB Gene IDBG-39809.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NSFL1C
Gene Name NSFL1 (p97) cofactor (p47)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000088833
Encoded Proteins
NSFL1 (p97) cofactor (p47)
NSFL1 (p97) cofactor (p47)
NSFL1 (p97) cofactor (p47)
NSFL1 (p97) cofactor (p47)
NSFL1 (p97) cofactor (p47)
NSFL1 (p97) cofactor (p47)
NSFL1 (p97) cofactor (p47)
NSFL1 (p97) cofactor (p47)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary N-ethylmaleimide-sensitive factor (NSF) and valosin-containing protein (p97) are two ATPases known to be involved in transport vesicle/target membrane fusion and fusions between membrane compartments. A trimer of the protein encoded by this gene binds a hexamer of cytosolic p97 and is required for p97-mediated regrowth of Golgi cisternae from mitotic Golgi fragments. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 8. [provided by RefSeq, May 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 20:1442162-1473842
Strand Reverse strand
Band p13
Transcripts
ENST00000381653 ENSP00000434067
ENST00000216879 ENSP00000216879
ENST00000353088 ENSP00000338643
ENST00000461211
ENST00000476071 ENSP00000418529
ENST00000470376 ENSP00000473400
ENST00000489203 ENSP00000473616
ENST00000487086
ENST00000478168
ENST00000555944 ENSP00000452019
ENST00000555568 ENSP00000451675
ENST00000555359
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 60 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 60 [view]
Protein-Protein 60 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008289 lipid binding
Biological Process
Cellular Component
GO:0005634 nucleus
GO:0005694 chromosome
GO:0005737 cytoplasm
GO:0005795 Golgi stack
GO:0005886 plasma membrane
GO:0045111 intermediate filament cytoskeleton
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
Protein processing in endoplasmic reticulum pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.598664 Hs.622160
RefSeq NM_001206736 NM_016143 NM_018839 XM_006723591 XM_006723592 XM_006723593 XM_006723594
HUGO
OMIM
CCDS CCDS13015 CCDS13016 CCDS56175
HPRD 09425
IMGT
EMBL
GenPept
RNA Seq Atlas