Homo sapiens Gene: CMA1
Summary
InnateDB Gene IDBG-3997.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CMA1
Gene Name chymase 1, mast cell
Synonyms chymase; CYH; MCT1;
Species Homo sapiens
Ensembl Gene ENSG00000092009
Encoded Proteins
chymase 1, mast cell
chymase 1, mast cell
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
Mast cell chymase CMA1 contributes to the control of inflammation by degrading the virulence factor Hsp70 of Trichinella spiralis, as well as several alarmins such as endogenous HSPA1A, BGN, and HMGB1..
Entrez Gene
Summary This gene product is a chymotryptic serine proteinase that belongs to the peptidase family S1. It is expressed in mast cells and thought to function in the degradation of the extracellular matrix, the regulation of submucosal gland secretion, and the generation of vasoactive peptides. In the heart and blood vessels, this protein, rather than angiotensin converting enzyme, is largely responsible for converting angiotensin I to the vasoactive peptide angiotensin II. Angiotensin II has been implicated in blood pressure control and in the pathogenesis of hypertension, cardiac hypertrophy, and heart failure. Thus, this gene product is a target for cardiovascular disease therapies. This gene maps to 14q11.2 in a cluster of genes encoding other proteases. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:24505353-24508265
Strand Reverse strand
Band q12
Transcripts
ENST00000250378 ENSP00000250378
ENST00000206446 ENSP00000206446
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
Experimentally validated
Total 16 [view]
Protein-Protein 15 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004252 serine-type endopeptidase activity
GO:0008236 serine-type peptidase activity
GO:0042277 peptide binding
Biological Process
GO:0002003 angiotensin maturation
GO:0006508 proteolysis
GO:0006518 peptide metabolic process
GO:0022617 extracellular matrix disassembly
GO:0030198 extracellular matrix organization
GO:0030901 midbrain development
GO:0044267 cellular protein metabolic process
GO:0045087 innate immune response (InnateDB)
GO:0045766 positive regulation of angiogenesis
GO:0050720 interleukin-1 beta biosynthetic process
GO:0050727 regulation of inflammatory response
GO:0071333 cellular response to glucose stimulus
Cellular Component
GO:0005576 extracellular region
GO:0005622 intracellular
GO:0030141 secretory granule
GO:0031012 extracellular matrix
Orthologs
Species
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
Low
Tentative data, uncurated. RBBH derived.
Pathways
NETPATH
REACTOME
Extracellular matrix organization pathway
Degradation of the extracellular matrix pathway
Metabolism of Angiotensinogen to Angiotensins pathway
Activation of Matrix Metalloproteinases pathway
Signaling by SCF-KIT pathway
Signal Transduction pathway
Metabolism of proteins pathway
Peptide hormone metabolism pathway
KEGG
Renin-angiotensin system pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL Q3SY37
UniProt Splice Variant
Entrez Gene 1215
UniGene Hs.135626
RefSeq NM_001836
HUGO HGNC:2097
OMIM 118938
CCDS CCDS9630
HPRD 00346
IMGT
EMBL AL132800 BC103974
GenPept AAI03975
RNA Seq Atlas 1215