Version 5.4
Homo sapiens Gene: NDUFA13
Summary
InnateDB Gene IDBG-39983.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NDUFA13
Gene Name NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000186010
Encoded Proteins
IDBP-766011
IDBP-474349
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13
IDBP-762969
IDBP-759728
IDBP-810127
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 15753091
YJEFN3 is a downstream effector of anti-bacterial function in intestinal epithelial cells that is required for NOD2-mediated NF-kappaB activation following NOD2 mediated recognition of bacterial muramyl dipeptide (MDP).
PMID 12163600
YJEFN3 (NDUFA13) interacts with viral interferon regulatory factor 1 of Kaposi's sarcoma-associated herpesvirus and inhibits interferon/retinoic acid-induced cell death.
PMID 17928352
YJEFN3 belongs to the family of genes associated with retinoid-interferon mortality and serves as an essential component of the oxidative phosphorylation system. YJEFN3 interacts with human herpesvirus 6B U95 protein and the resulting silencing of U95 expression reduces viral load and abrogates loss of mitochondrial membrane potential.
PMID 17823279
YJEFN3 blocks SRC-induced gene expression through STAT3 and activation of cell adhesion molecules.
Entrez Gene
Summary This gene encodes a subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), which functions in the transfer of electrons from NADH to the respiratory chain. The protein is required for complex I assembly and electron transfer activity. The protein binds the signal transducers and activators of transcription 3 (STAT3) transcription factor, and can function as a tumor suppressor. The human protein purified from mitochondria migrates at approximately 16 kDa. Transcripts originating from an upstream promoter and capable of expressing a protein with a longer N-terminus have been found, but their biological validity has not been determined. [provided by RefSeq, Oct 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:19515736-19529054
Strand Forward strand
Band p13.11
Transcripts
ENST00000428459 ENSP00000465129
ENST00000507754 ENSP00000423673
ENST00000503283 ENSP00000468317
ENST00000511584
ENST00000502506 ENSP00000467274
ENST00000511180
ENST00000606722 ENSP00000476093
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 14 [view]
Protein-Protein 14 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003954 NADH dehydrogenase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008137 NADH dehydrogenase (ubiquinone) activity
Biological Process
GO:0022904 respiratory electron transport chain
GO:0030308 negative regulation of cell growth
GO:0044237 cellular metabolic process
GO:0044281 small molecule metabolic process
GO:0045039 protein import into mitochondrial inner membrane
GO:0045087 innate immune response (InnateDB)
GO:0045892 negative regulation of transcription, DNA-templated
GO:0072593 reactive oxygen species metabolic process
GO:0097190 apoptotic signaling pathway
GO:2001243 negative regulation of intrinsic apoptotic signaling pathway
Cellular Component
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005746 mitochondrial respiratory chain
GO:0005747 mitochondrial respiratory chain complex I
GO:0016021 integral component of membrane
GO:0031966 mitochondrial membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000036199
View Gene Order
ENSBTAG00000007812
Not yet available
Pathways
NETPATH
NetPath_4
EGFR1 pathway
REACTOME
REACT_22393
Respiratory electron transport pathway
REACT_6305
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. pathway
REACT_111083
The citric acid (TCA) cycle and respiratory electron transport pathway
REACT_111217
Metabolism pathway
KEGG
hsa05010
Alzheimer's disease pathway
hsa00190
Oxidative phosphorylation pathway
hsa05012
Parkinson's disease pathway
hsa05016
Huntington's disease pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_015965
HUGO
OMIM
CCDS CCDS12404
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca