InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NDUFA13

Summary

InnateDB Protein

IDBP-474349.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NDUFA13

Protein Name

NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000423673

InnateDB Gene

IDBG-39983 (NDUFA13)

Protein Structure

UniProt Annotation

Function

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Involved in the interferon/all-trans-retinoic acid (IFN/RA) induced cell death. This apoptotic activity is inhibited by interaction with viral IRF1. Prevents the transactivation of STAT3 target genes. May play a role in CARD15-mediated innate mucosal responses and serve to regulate intestinal epithelial cell responses to microbes. {ECO:0000269PubMed:12628925, ECO:0000269PubMed:12867595, ECO:0000269PubMed:15753091}.

Subcellular Localization

Mitochondrion inner membrane; Single-pass membrane protein; Matrix side. Nucleus. Note=May be translocated into the nucleus upon IFN/RA treatment.

Disease Associations

Hurthle cell thyroid carcinoma (HCTC) [MIM:607464]: A rare type of thyroid cancer accounting for only about 3-10% of all differentiated thyroid cancers. These neoplasms are considered a variant of follicular carcinoma of the thyroid and are referred to as follicular carcinoma, oxyphilic type. {ECO:0000269PubMed:15841082}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Tissue Specificity

Widely expressed, with highest expression in heart, skeletal muscle, liver, kidney and placenta. In intestinal mucosa, down-regulated in areas involved in Crohn disease and ulcerative colitis. {ECO:0000269PubMed:10924506}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	14 [view]
Protein-Protein	14 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003954	NADH dehydrogenase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008137	NADH dehydrogenase (ubiquinone) activity

Biological Process

GO:0022904	respiratory electron transport chain
GO:0030308	negative regulation of cell growth
GO:0044237	cellular metabolic process
GO:0044281	small molecule metabolic process
GO:0045039	protein import into mitochondrial inner membrane
GO:0045087	innate immune response (InnateDB)
GO:0045892	negative regulation of transcription, DNA-templated
GO:0072593	reactive oxygen species metabolic process
GO:0097190	apoptotic signaling pathway
GO:2001243	negative regulation of intrinsic apoptotic signaling pathway

Cellular Component

GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0005746	mitochondrial respiratory chain
GO:0005747	mitochondrial respiratory chain complex I
GO:0016021	integral component of membrane
GO:0031966	mitochondrial membrane
GO:0070062	extracellular vesicular exosome