Version 5.4
Homo sapiens Gene: SHARPIN
Summary
InnateDB Gene IDBG-40065.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SHARPIN
Gene Name SHANK-associated RH domain interactor
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000179526
Encoded Proteins
IDBP-40067
SHANK-associated RH domain interactor
IDBP-232393
SHANK-associated RH domain interactor
IDBP-584063
SHANK-associated RH domain interactor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 21709223
SHARPIN is an essential adaptor downstream of IKBKG in the TLR signalling pathway. A mutation in the SHARPIN gene impairs IL12 production in TLR-stimulated macrophages.
PMID 22348129
SHARPIN deficient dendritic cells show reduced inflammatory cytokine production, defective NF-kB signalling and skewing towards a Th2-response. (Demonstrated in mice)
InnateDB Annotation from Orthologs
Summary
PMID 21709223
[Mus musculus] Sharpin is an essential adaptor downstream of Ikbkg in the TLR signalling pathway. A mutation in the Sharpin gene impairs Il12 production in TLR-stimulated macrophages.
PMID 22348129
[Mus musculus] Sharpin deficient dendritic cells show reduced inflammatory cytokine production, defective NF-kB signalling and skewing towards a Th2-response.
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 8:144098633-144108124
Strand Reverse strand
Band q24.3
Transcripts
ENST00000359551 ENSP00000352551
ENST00000398712 ENSP00000381698
ENST00000532536 ENSP00000432355
ENST00000530216
ENST00000534242
ENST00000525275
ENST00000533948
ENST00000534435
ENST00000531375
ENST00000533184
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 44 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.
Experimentally validated
Total 44 [view]
Protein-Protein 44 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 23 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0031593 polyubiquitin binding
GO:0032403 protein complex binding
GO:0042802 identical protein binding
Biological Process
GO:0007005 mitochondrion organization
GO:0007420 brain development
GO:0008544 epidermis development
GO:0010803 regulation of tumor necrosis factor-mediated signaling pathway
GO:0030262 apoptotic nuclear changes
GO:0031424 keratinization
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045087 innate immune response (InnateDB)
GO:0050728 negative regulation of inflammatory response
GO:0051260 protein homooligomerization
GO:0097039 protein linear polyubiquitination
GO:2000348 regulation of CD40 signaling pathway
Cellular Component
GO:0005829 cytosol
GO:0014069 postsynaptic density
GO:0030054 cell junction
GO:0030425 dendrite
GO:0071797 LUBAC complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000022552
View Gene Order
ENSBTAG00000012235
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_030974
HUGO
OMIM
CCDS CCDS43777
HPRD 15463
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca