Homo sapiens Gene: IL10RB
Summary
InnateDB Gene IDBG-401888.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IL10RB
Gene Name interleukin 10 receptor, beta
Synonyms CDW210B; CRF2-4; CRFB4; D21S58; D21S66; IL-10R2;
Species Homo sapiens
Ensembl Gene ENSG00000243646
Encoded Proteins
interleukin 10 receptor, beta
interleukin 10 receptor, beta
interleukin 10 receptor, beta
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene belongs to the cytokine receptor family. It is an accessory chain essential for the active interleukin 10 receptor complex. Coexpression of this and IL10RA proteins has been shown to be required for IL10-induced signal transduction. This gene and three other interferon receptor genes, IFAR2, IFNAR1, and IFNGR2, form a class II cytokine receptor gene cluster located in a small region on chromosome 21. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 21:33266358-33297234
Strand Forward strand
Band q22.11
Transcripts
ENST00000290200 ENSP00000290200
ENST00000422891 ENSP00000414682
ENST00000451065 ENSP00000397611
ENST00000493295
ENST00000498371
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 4 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004872 receptor activity
GO:0004920 interleukin-10 receptor activity
GO:0005515 protein binding
Biological Process
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0007165 signal transduction
GO:0019221 cytokine-mediated signaling pathway
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
GO:0032002 interleukin-28 receptor complex
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
Cytokine-cytokine receptor interaction pathway
Jak-STAT signaling pathway pathway
Toxoplasmosis pathway
INOH
IL-10 signaling pathway
JAK STAT pathway and regulation pathway
PID BIOCARTA
Il-10 anti-inflammatory signaling pathway [Biocarta view]
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.654593
RefSeq NM_000628
HUGO
OMIM
CCDS CCDS13623
HPRD 00473
IMGT
EMBL
GenPept
RNA Seq Atlas