InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: IL10RB

Summary

InnateDB Protein

IDBP-2055.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IL10RB

Protein Name

interleukin 10 receptor, beta

Synonyms

CDW210B; CRF2-4; CRFB4; D21S58; D21S66; IL-10R2;

Species

Homo sapiens

Ensembl Protein

ENSP00000290200

InnateDB Gene

IDBG-401888 (IL10RB)

Protein Structure

UniProt Annotation

Function

Shared cell surface receptor required for the activation of five class 2 cytokines: IL10, IL22, IL26, IL28, and IFNL1. The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state. {ECO:0000269PubMed:12469119, ECO:0000269PubMed:15123776}.

Subcellular Localization

Membrane; Single-pass type I membrane protein.

Disease Associations

Inflammatory bowel disease 25 (IBD25) [MIM:612567]: A chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. It is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may affect any part of the gastrointestinal tract from the mouth to the anus, but most frequently it involves the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints. {ECO:0000269PubMed:19890111}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	4 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0004920	interleukin-10 receptor activity
GO:0005515	protein binding

Biological Process

GO:0006954	inflammatory response
GO:0006955	immune response
GO:0007165	signal transduction
GO:0007596	blood coagulation
GO:0019221	cytokine-mediated signaling pathway