Version 5.4
Homo sapiens Gene: SCARF2
Summary
InnateDB Gene IDBG-401942.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SCARF2
Gene Name scavenger receptor class F, member 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000244486
Encoded Proteins
IDBP-812401
scavenger receptor class F, member 2
IDBP-812403
scavenger receptor class F, member 2
IDBP-812413
scavenger receptor class F, member 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is similar to SCARF1/SREC-I, a scavenger receptor protein that mediates the binding and degradation of acetylated low density lipoprotein (Ac-LDL). This protein has only little activity of internalizing modified low density lipoproteins (LDL), but it can interact with SCARF1 through its extracellular domain. The association of this protein with SCARF1 is suppressed by the presence of scavenger ligands. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 22:20424585-20437859
Strand Reverse strand
Band q11.21
Transcripts
ENST00000494535
ENST00000622235 ENSP00000477564
ENST00000623402 ENSP00000485276
ENST00000615031 ENSP00000479389
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005044 scavenger receptor activity
GO:0005515 protein binding
Biological Process
GO:0006898 receptor-mediated endocytosis
GO:0007157 heterophilic cell-cell adhesion
Cellular Component
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000012017
View Gene Order
ENSBTAG00000019375
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 91179
UniGene Hs.474251
RefSeq NM_153334 NM_182895
HUGO HGNC:19869
OMIM 613619
CCDS CCDS46666
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas 91179

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca