Version 5.4
Homo sapiens Gene: NFS1
Summary
InnateDB Gene IDBG-402145.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NFS1
Gene Name NFS1 nitrogen fixation 1 homolog (S. cerevisiae)
Synonyms IscS; NIFS
Species Homo sapiens
Ensembl Gene ENSG00000244005
Encoded Proteins
IDBP-71238
NFS1 nitrogen fixation 1 homolog (S. cerevisiae)
IDBP-71240
NFS1 nitrogen fixation 1 homolog (S. cerevisiae)
IDBP-71242
NFS1 nitrogen fixation 1 homolog (S. cerevisiae)
IDBP-235391
NFS1 nitrogen fixation 1 homolog (S. cerevisiae)
IDBP-373697
NFS1 nitrogen fixation 1 homolog (S. cerevisiae)
IDBP-373701
NFS1 nitrogen fixation 1 homolog (S. cerevisiae)
IDBP-373735
NFS1 nitrogen fixation 1 homolog (S. cerevisiae)
IDBP-373738
NFS1 nitrogen fixation 1 homolog (S. cerevisiae)
IDBP-373743
NFS1 nitrogen fixation 1 homolog (S. cerevisiae)
IDBP-373744
NFS1 nitrogen fixation 1 homolog (S. cerevisiae)
IDBP-585139
NFS1 nitrogen fixation 1 homolog (S. cerevisiae)
IDBP-589787
NFS1 nitrogen fixation 1 homolog (S. cerevisiae)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Iron-sulfur clusters are required for the function of many cellular enzymes. The proteins encoded by this gene supply inorganic sulfur to these clusters by removing the sulfur from cysteine, creating alanine in the process. This gene uses alternate in-frame translation initiation sites to generate mitochondrial forms and cytoplasmic/nuclear forms. Selection of the alternative initiation sites is determined by the cytosolic pH. The encoded proteins belong to the class-V family of pyridoxal phosphate-dependent aminotransferases. Alternatively spliced transcript variants have been described. [provided by RefSeq, Nov 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 20:35668055-35699359
Strand Reverse strand
Band q11.22
Transcripts
ENST00000374092 ENSP00000363205
ENST00000374085 ENSP00000363198
ENST00000306750 ENSP00000304740
ENST00000397425 ENSP00000380570
ENST00000454607 ENSP00000395201
ENST00000441563 ENSP00000411232
ENST00000440385 ENSP00000392871
ENST00000413203 ENSP00000393669
ENST00000456462 ENSP00000397572
ENST00000419569 ENSP00000393482
ENST00000421540
ENST00000480655
ENST00000498084
ENST00000471137
ENST00000489163
ENST00000541176 ENSP00000443983
ENST00000541387 ENSP00000440897
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 3 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0005515 protein binding
GO:0016829 lyase activity
GO:0030170 pyridoxal phosphate binding
GO:0031071 cysteine desulfurase activity
GO:0042803 protein homodimerization activity
Biological Process
GO:0000096 sulfur amino acid metabolic process
GO:0006461 protein complex assembly
GO:0006520 cellular amino acid metabolic process
GO:0006534 cysteine metabolic process
GO:0006766 vitamin metabolic process
GO:0006767 water-soluble vitamin metabolic process
GO:0006777 Mo-molybdopterin cofactor biosynthetic process
GO:0008152 metabolic process
GO:0018283 iron incorporation into metallo-sulfur cluster
GO:0032324 molybdopterin cofactor biosynthetic process
GO:0044281 small molecule metabolic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000027618
View Gene Order
ENSBTAG00000006962
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa00730
Thiamine metabolism pathway
hsa04122
Sulfur relay system pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.194692
RefSeq NM_001198989 NM_021100
HUGO
OMIM
CCDS CCDS13262 CCDS56185
HPRD 04597
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca