Bos taurus Gene: NFS1
InnateDB Gene IDBG-642247.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NFS1
Gene Name cysteine desulfurase, mitochondrial
Species Bos taurus
Ensembl Gene ENSBTAG00000006962
Encoded Proteins
cysteine desulfurase, mitochondrial
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000244005:
Iron-sulfur clusters are required for the function of many cellular enzymes. The proteins encoded by this gene supply inorganic sulfur to these clusters by removing the sulfur from cysteine, creating alanine in the process. This gene uses alternate in-frame translation initiation sites to generate mitochondrial forms and cytoplasmic/nuclear forms. Selection of the alternative initiation sites is determined by the cytosolic pH. The encoded proteins belong to the class-V family of pyridoxal phosphate-dependent aminotransferases. Alternatively spliced transcript variants have been described. [provided by RefSeq, Nov 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:65545941-65563035
Strand Reverse strand
ENSBTAT00000009149 ENSBTAP00000009149
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0005515 protein binding
GO:0016829 lyase activity
GO:0030170 pyridoxal phosphate binding
GO:0031071 cysteine desulfurase activity
GO:0042803 protein homodimerization activity
Biological Process
GO:0006520 cellular amino acid metabolic process
GO:0006534 cysteine metabolic process
GO:0008152 metabolic process
GO:0018283 iron incorporation into metallo-sulfur cluster
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0005829 cytosol
Mus musculus
Homo sapiens
Gene ID
Gene Order
Pathway Predictions based on Human Orthology Data
Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF pathway
Disease pathway
Metabolism pathway
Defective AMN causes hereditary megaloblastic anemia 1 pathway
Defective GIF causes intrinsic factor deficiency pathway
Defective MMAA causes methylmalonic aciduria type cblA pathway
Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC pathway
Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD pathway
Defective CD320 causes methylmalonic aciduria pathway
Defective MUT causes methylmalonic aciduria mut type pathway
Defects in biotin (Btn) metabolism pathway
Defective BTD causes biotidinase deficiency pathway
Defective MMAB causes methylmalonic aciduria type cblB pathway
Defective MTR causes methylmalonic aciduria and homocystinuria type cblG pathway
Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE pathway
Defective CUBN causes hereditary megaloblastic anemia 1 pathway
Metabolism of vitamins and cofactors pathway
Metabolism of water-soluble vitamins and cofactors pathway
Defects in vitamin and cofactor metabolism pathway
Defects in cobalamin (B12) metabolism pathway
Defective TCN2 causes hereditary megaloblastic anemia pathway
Mitochondrial iron-sulfur cluster biogenesis pathway
Molybdenum cofactor biosynthesis pathway
Defective HLCS causes multiple carboxylase deficiency pathway
Thiamine metabolism pathway
Sulfur relay system pathway
Thiamine metabolism pathway
Sulfur relay system pathway
UniProt Splice Variant
Entrez Gene
UniGene Bt.32501
RefSeq NM_001099001
RNA Seq Atlas