Version 5.4
Homo sapiens Gene: POU4F2
Summary
InnateDB Gene IDBG-40221.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol POU4F2
Gene Name POU class 4 homeobox 2
Synonyms Brn-3b; BRN3.2; BRN3B
Species Homo sapiens
Ensembl Gene ENSG00000151615
Encoded Proteins
IDBP-40223
POU class 4 homeobox 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the POU-domain transcription factor family and may be involved in maintaining visual system neurons in the retina. The level of the encoded protein is also elevated in a majority of breast cancers, resulting in accelerated tumor growth. [provided by RefSeq, Sep 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:146638893-146642474
Strand Forward strand
Band q31.22
Transcripts
ENST00000281321 ENSP00000281321
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001078 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003700 sequence-specific DNA binding transcription factor activity
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0000165 MAPK cascade
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007399 nervous system development
GO:0007409 axonogenesis
GO:0007411 axon guidance
GO:0007605 sensory perception of sound
GO:0030182 neuron differentiation
GO:0030520 intracellular estrogen receptor signaling pathway
GO:0031290 retinal ganglion cell axon guidance
GO:0045597 positive regulation of cell differentiation
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048675 axon extension
GO:0050885 neuromuscular process controlling balance
GO:0060041 retina development in camera-type eye
Cellular Component
GO:0005634 nucleus
GO:0016607 nuclear speck
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000031688
View Gene Order
ENSBTAG00000005648
Not yet available
Pathways
NETPATH
REACTOME
KEGG
INOH
PID NCI
era_genomic_pathway
Validated nuclear estrogen receptor alpha network
p53downstreampathway
Direct p53 effectors
Cross-References
SwissProt Q12837
TrEMBL
UniProt Splice Variant
Entrez Gene 5458
UniGene Hs.266
RefSeq NM_004575
HUGO HGNC:9219
OMIM 113725
CCDS CCDS34074
HPRD
IMGT
EMBL AC093887 AK314982 BC136344 BC136345 EU439706 L20434 U06233 X71488
GenPept AAA16509 AAA36393 AAI36345 AAI36346 ACA49233 BAG37481 CAA50589
RNA Seq Atlas 5458

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca