InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: POU4F2

Summary

InnateDB Protein

IDBP-40223.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

POU4F2

Protein Name

POU class 4 homeobox 2

Synonyms

Brn-3b; BRN3.2; BRN3B;

Species

Homo sapiens

Ensembl Protein

ENSP00000281321

InnateDB Gene

IDBG-40221 (POU4F2)

Protein Structure

UniProt Annotation

Function

Transcription factor. May play a role in determining or maintaining the identities of a small subset of visual system neurons.

Subcellular Localization

Nucleus speckle {ECO:0000255PROSITE- ProRule:PRU00108, ECO:0000255PROSITE-ProRule:PRU00530, ECO:0000269PubMed:19266028}.

Disease Associations

Tissue Specificity

Brain. Seems to be specific to the retina.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	1 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001078	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0000165	MAPK cascade
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007399	nervous system development
GO:0007409	axonogenesis
GO:0007411	axon guidance
GO:0007605	sensory perception of sound
GO:0030182	neuron differentiation
GO:0030520	intracellular estrogen receptor signaling pathway
GO:0031290	retinal ganglion cell axon guidance
GO:0045597	positive regulation of cell differentiation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048675	axon extension
GO:0050885	neuromuscular process controlling balance
GO:0060041	retina development in camera-type eye