Homo sapiens Gene: APOBEC3G
Summary
InnateDB Gene IDBG-402349.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol APOBEC3G
Gene Name apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000239713
Encoded Proteins
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
APOBEC3G is an innate intracellular HIV restriction factor that is upregulated by type I interferons.
APOBEC3G, an intrinsic antiviral factor, promotes the recognition of human immunodeficiency virus (HIV) through the activation of the DNA-damage response pathway and the expression of natural killer cell-activating ligands on HIV-infected cells.
Entrez Gene
Summary This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. It is thought that the proteins may be RNA editing enzymes and have roles in growth or cell cycle control. The protein encoded by this gene has been found to be a specific inhibitor of human immunodeficiency virus-1 (HIV-1) infectivity. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 22:39040961-39087743
Strand Forward strand
Band q13.1
Transcripts
ENST00000407997 ENSP00000385057
ENST00000452957 ENSP00000413376
ENST00000463934
ENST00000480000
ENST00000461827
ENST00000486357
ENST00000494150
ENST00000481958
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
Experimentally validated
Total 14 [view]
Protein-Protein 14 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003723 RNA binding
GO:0003824 catalytic activity
GO:0004126 cytidine deaminase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
GO:0042803 protein homodimerization activity
GO:0047844 deoxycytidine deaminase activity
Biological Process
GO:0002230 positive regulation of defense response to virus by host
GO:0009972 cytidine deamination
GO:0010529 negative regulation of transposition
GO:0016032 viral process
GO:0016553 base conversion or substitution editing
GO:0045071 negative regulation of viral genome replication
GO:0045087 innate immune response (InnateDB)
GO:0045869 negative regulation of single stranded viral RNA replication via double stranded DNA intermediate
GO:0048525 negative regulation of viral process
GO:0051607 defense response to virus
GO:0070383 DNA cytosine deamination
Cellular Component
GO:0000932 cytoplasmic mRNA processing body
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0030529 ribonucleoprotein complex
GO:0030895 apolipoprotein B mRNA editing enzyme complex
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
KEGG
INOH
PID BIOCARTA
Hiv-1 defeats host-mediated resistance by cem15 [Biocarta view]
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_021822
HUGO
OMIM
CCDS CCDS13984
HPRD 06172
IMGT
EMBL
GenPept
RNA Seq Atlas