InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: APOBEC3G

Summary

InnateDB Gene

IDBG-402349.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

APOBEC3G

Gene Name

apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000239713

Encoded Proteins

IDBP-293480

apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G

IDBP-377050

apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 21734563

APOBEC3G is an innate intracellular HIV restriction factor that is upregulated by type I interferons.

PMID 21874023

APOBEC3G, an intrinsic antiviral factor, promotes the recognition of human immunodeficiency virus (HIV) through the activation of the DNA-damage response pathway and the expression of natural killer cell-activating ligands on HIV-infected cells.

Entrez Gene

Summary

This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. It is thought that the proteins may be RNA editing enzymes and have roles in growth or cell cycle control. The protein encoded by this gene has been found to be a specific inhibitor of human immunodeficiency virus-1 (HIV-1) infectivity. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 22:39040961-39087743

Strand

Forward strand

Band

q13.1

Transcripts

ENST00000407997	ENSP00000385057
ENST00000452957	ENSP00000413376
ENST00000463934
ENST00000480000
ENST00000461827
ENST00000486357
ENST00000494150
ENST00000481958

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.

Experimentally validated
Total	14 [view]
Protein-Protein	14 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003723	RNA binding
GO:0003824	catalytic activity
GO:0004126	cytidine deaminase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016814	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
GO:0042803	protein homodimerization activity
GO:0047844	deoxycytidine deaminase activity

Biological Process

GO:0002230	positive regulation of defense response to virus by host
GO:0009972	cytidine deamination
GO:0010529	negative regulation of transposition
GO:0016032	viral process
GO:0016553	base conversion or substitution editing
GO:0045071	negative regulation of viral genome replication
GO:0045087	innate immune response (InnateDB)
GO:0045869	negative regulation of single stranded viral RNA replication via double stranded DNA intermediate
GO:0048525	negative regulation of viral process
GO:0051607	defense response to virus
GO:0070383	DNA cytosine deamination

Cellular Component

GO:0000932	cytoplasmic mRNA processing body
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0030529	ribonucleoprotein complex
GO:0030895	apolipoprotein B mRNA editing enzyme complex

Orthologs

No orthologs found for this gene

Pathways

NETPATH

REACTOME

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

RefSeq

NM_021822

HUGO

OMIM

CCDS

CCDS13984

HPRD

06172

IMGT

EMBL

GenPept

RNA Seq Atlas