Homo sapiens Gene: SF3B3
Summary
InnateDB Gene IDBG-40245.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SF3B3
Gene Name splicing factor 3b, subunit 3, 130kDa
Synonyms RSE1; SAP130; SF3b130; STAF130;
Species Homo sapiens
Ensembl Gene ENSG00000189091
Encoded Proteins
splicing factor 3b, subunit 3, 130kDa
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes subunit 3 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. Subunit 3 has also been identified as a component of the STAGA (SPT3-TAF(II)31-GCN5L acetylase) transcription coactivator-HAT (histone acetyltransferase) complex, and the TFTC (TATA-binding-protein-free TAF(II)-containing complex). These complexes may function in chromatin modification, transcription, splicing, and DNA repair. [provided by RefSeq, Jul 2008]
This gene encodes subunit 3 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron\'s branch site in a sequence independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. Subunit 3 has also been identified as a component of the STAGA (SPT3-TAF(II)31-GCN5L acetylase) transcription coactivator-HAT (histone acetyltransferase) complex, and the TFTC (TATA-binding-protein-free TAF(II)-containing complex). These complexes may function in chromatin modification, transcription, splicing, and DNA repair. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:70523788-70577670
Strand Forward strand
Band q22.1
Transcripts
ENST00000302516 ENSP00000305790
ENST00000563739
ENST00000572365
ENST00000562722
ENST00000566095 ENSP00000454308
ENST00000569687 ENSP00000464126
ENST00000565990
ENST00000568291
ENST00000567635 ENSP00000463253
ENST00000577085 ENSP00000461236
ENST00000567654 ENSP00000463359
ENST00000564899 ENSP00000461342
ENST00000568539
ENST00000567250
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 167 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 167 [view]
Protein-Protein 167 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0005515 protein binding
Biological Process
GO:0000375 RNA splicing, via transesterification reactions
GO:0000398 mRNA splicing, via spliceosome
GO:0006397 mRNA processing
GO:0006461 protein complex assembly
GO:0008380 RNA splicing
GO:0010467 gene expression
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005681 spliceosomal complex
GO:0005689 U12-type spliceosomal complex
GO:0030532 small nuclear ribonucleoprotein complex
GO:0071013 catalytic step 2 spliceosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
mRNA Splicing - Minor Pathway pathway
Processing of Capped Intron-Containing Pre-mRNA pathway
mRNA Splicing pathway
Gene Expression pathway
mRNA Splicing - Major Pathway pathway
KEGG
Spliceosome pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL J3QL37 J3QRB2
UniProt Splice Variant
Entrez Gene 23450
UniGene Hs.514435 Hs.606443 Hs.732929
RefSeq NM_012426
HUGO HGNC:10770
OMIM 605592
CCDS CCDS10894
HPRD 12027
IMGT
EMBL AC106804
GenPept
RNA Seq Atlas 23450