Homo sapiens Gene: TNFRSF6B
Summary
InnateDB Gene IDBG-402658.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TNFRSF6B
Gene Name tumor necrosis factor receptor superfamily, member 6b, decoy
Synonyms DCR3; DJ583P15.1.1; M68; M68E; TR6
Species Homo sapiens
Ensembl Gene ENSG00000243509
Encoded Proteins
tumor necrosis factor receptor superfamily, member 6b, decoy
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene belongs to the tumor necrosis factor receptor superfamily. The encoded protein is postulated to play a regulatory role in suppressing FasL- and LIGHT-mediated cell death. It acts as a decoy receptor that competes with death receptors for ligand binding. Over-expression of this gene has been noted in gastrointestinal tract tumors. Read-through transcription into this gene from the neighboring upstream gene, which encodes regulator of telomere elongation helicase 1 (RTEL1), generates a non-coding transcript. [provided by RefSeq, Feb 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 20:63696668-63698684
Strand Forward strand
Band q13.33
Transcripts
ENST00000369996 ENSP00000359013
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004872 receptor activity
GO:0005515 protein binding
Biological Process
GO:0006915 apoptotic process
GO:0043066 negative regulation of apoptotic process
Cellular Component
GO:0005615 extracellular space
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
KEGG
Cytokine-cytokine receptor interaction pathway
INOH
PID NCI
Cross-References
SwissProt O95407
TrEMBL H0UI95
UniProt Splice Variant
Entrez Gene 8771
UniGene
RefSeq NM_003823
HUGO HGNC:11921
OMIM 603361
CCDS CCDS13532
HPRD
IMGT
EMBL AF104419 AF134240 AF217793 AF217794 AF217796 AL121845 AY358279 BC017065 BC034349 CH471077
GenPept AAD03056 AAD29688 AAF33685 AAF33686 AAF35244 AAH17065 AAH34349 AAQ88646 CAC03668 EAW75247 EAW75248
RNA Seq Atlas 8771