Homo sapiens Gene: ATP6V1F
Summary
InnateDB Gene IDBG-40301.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ATP6V1F
Gene Name ATPase, H+ transporting, lysosomal 14kDa, V1 subunit F
Synonyms ATP6S14; VATF; Vma7;
Species Homo sapiens
Ensembl Gene ENSG00000128524
Encoded Proteins
ATPase, H+ transporting, lysosomal 14kDa, V1 subunit F
ATPase, H+ transporting, lysosomal 14kDa, V1 subunit F
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c", and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is the V1 domain F subunit protein. [provided by RefSeq, Jul 2008]
This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c\', c", and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is the V1 domain F subunit protein. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:128862826-128865844
Strand Forward strand
Band q32.1
Transcripts
ENST00000249289 ENSP00000249289
ENST00000492758 ENSP00000417378
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 40 experimentally validated interaction(s) in this database.
Experimentally validated
Total 40 [view]
Protein-Protein 39 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0015078 hydrogen ion transmembrane transporter activity
GO:0042624 ATPase activity, uncoupled
GO:0042625 ATPase activity, coupled to transmembrane movement of ions
GO:0046961 proton-transporting ATPase activity, rotational mechanism
Biological Process
GO:0006200 ATP catabolic process
GO:0006879 cellular iron ion homeostasis
GO:0008286 insulin receptor signaling pathway
GO:0015991 ATP hydrolysis coupled proton transport
GO:0015992 proton transport
GO:0033572 transferrin transport
GO:0034220 ion transmembrane transport
GO:0051701 interaction with host
GO:0055085 transmembrane transport
GO:0090382 phagosome maturation
Cellular Component
GO:0005829 cytosol
GO:0016020 membrane
GO:0016469 proton-transporting two-sector ATPase complex
GO:0016471 vacuolar proton-transporting V-type ATPase complex
GO:0033180 proton-transporting V-type ATPase, V1 domain
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Transmembrane transport of small molecules pathway
Iron uptake and transport pathway
Insulin receptor recycling pathway
Signal Transduction pathway
Transferrin endocytosis and recycling pathway
Phagosomal maturation (early endosomal stage) pathway
Signaling by Insulin receptor pathway
Latent infection of Homo sapiens with Mycobacterium tuberculosis pathway
Disease pathway
KEGG
Oxidative phosphorylation pathway
Phagosome pathway
Collecting duct acid secretion pathway
Vibrio cholerae infection pathway
Epithelial cell signaling in Helicobacter pylori infection pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q16864
TrEMBL A4D1K0
UniProt Splice Variant
Entrez Gene 9296
UniGene
RefSeq NM_001198909 NM_004231
HUGO HGNC:16832
OMIM 607160
CCDS CCDS56511 CCDS5807
HPRD
IMGT
EMBL AC025594 AK312214 BC104230 BC104231 BC107854 BU956696 CH236950 CH471070 CR456896 D49400
GenPept AAI04231 AAI04232 AAI07855 BAA08392 BAG35147 CAG33177 EAL24110 EAW83692 EAW83693
RNA Seq Atlas 9296