Homo sapiens Gene: SEPP1
Summary
InnateDB Gene IDBG-404687.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SEPP1
Gene Name selenoprotein P, plasma, 1
Synonyms SELP; SeP;
Species Homo sapiens
Ensembl Gene ENSG00000250722
Encoded Proteins
selenoprotein P, plasma, 1
selenoprotein P, plasma, 1
selenoprotein P, plasma, 1
selenoprotein P, plasma, 1
selenoprotein P, plasma, 1
selenoprotein P, plasma, 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a selenoprotein containing multiple selenocysteine (Sec) residues, which are encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This selenoprotein is an extracellular glycoprotein, and is unusual in that it contains 10 Sec residues per polypeptide. It is a heparin-binding protein that appears to be associated with endothelial cells, and has been implicated to function as an antioxidant in the extracellular space. Several transcript variants, encoding either the same or different isoform, have been found for this gene. [provided by RefSeq, Jul 2008]
This gene encodes a selenoprotein containing multiple selenocysteine (Sec) residues, which are encoded by the UGA codon that normally signals translation termination. The 3\' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This selenoprotein is an extracellular glycoprotein, and is unusual in that it contains 10 Sec residues per polypeptide. It is a heparin-binding protein that appears to be associated with endothelial cells, and has been implicated to function as an antioxidant in the extracellular space. Several transcript variants, encoding either the same or different isoform, have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:42799880-42887392
Strand Reverse strand
Band p12
Transcripts
ENST00000514985 ENSP00000420939
ENST00000512980
ENST00000511224 ENSP00000427671
ENST00000506577 ENSP00000425915
ENST00000507920 ENSP00000473340
ENST00000509276
ENST00000514218 ENSP00000421626
ENST00000513303
ENST00000514403
ENST00000510965 ENSP00000427414
ENST00000505309
ENST00000506078
ENST00000510650
ENST00000515626
ENST00000508937
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0008430 selenium binding
Biological Process
GO:0001887 selenium compound metabolic process
GO:0006979 response to oxidative stress
GO:0007420 brain development
GO:0007626 locomotory behavior
GO:0009791 post-embryonic development
GO:0019953 sexual reproduction
GO:0040007 growth
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
Low
Tentative data, uncurated. RBBH derived.
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.610520 Hs.626354 Hs.743272 Hs.743778
RefSeq NM_001085486 NM_005410
HUGO
OMIM
CCDS CCDS43311
HPRD 03286
IMGT
EMBL
GenPept
RNA Seq Atlas