InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SEPP1

Summary

InnateDB Protein

IDBP-475443.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SEPP1

Protein Name

selenoprotein P, plasma, 1

Synonyms

SELP; SeP;

Species

Homo sapiens

Ensembl Protein

ENSP00000427671

InnateDB Gene

IDBG-404687 (SEPP1)

Protein Structure

UniProt Annotation

Function

Might be responsible for some of the extracellular antioxidant defense properties of selenium or might be involved in the transport of selenium. May supply selenium to tissues such as brain and testis.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Made in the liver and heart and secreted into the plasma. It is also found in the kidney.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008430	selenium binding

Biological Process

GO:0006979

response to oxidative stress

Cellular Component

GO:0005576	extracellular region
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR007671 Selenoprotein P, N-terminal
IPR007672 Selenoprotein P, C-terminal

PFAM

PF04592
PF04593

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P49908

PhosphoSite

PhosphoSite-P49908

TrEMBL

UniProt Splice Variant

Entrez Gene

6414

UniGene

Hs.743778

RefSeq

NP_001087195

HUGO

HGNC:10751

OMIM

601484

CCDS

CCDS43311

HPRD

03286

IMGT

EMBL

AC008945 BC005244 BC015875 BC040075 BC046152 BC058919 DQ022288 Z11793

GenPept

AAH15875 AAH40075 AAH46152 AAH58919 AAY26400 CAA77836