Homo sapiens Gene: WNT5A
Summary
InnateDB Gene IDBG-40713.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol WNT5A
Gene Name wingless-type MMTV integration site family, member 5A
Synonyms hWNT5A;
Species Homo sapiens
Ensembl Gene ENSG00000114251
Encoded Proteins
wingless-type MMTV integration site family, member 5A
wingless-type MMTV integration site family, member 5A
wingless-type MMTV integration site family, member 5A
wingless-type MMTV integration site family, member 5A
wingless-type MMTV integration site family, member 5A
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene encodes a member of the WNT family that signals through both the canonical and non-canonical WNT pathways. This protein is a ligand for the seven transmembrane receptor frizzled-5 and the tyrosine kinase orphan receptor 2. This protein plays an essential role in regulating developmental pathways during embryogenesis. This protein may also play a role in oncogenesis. Mutations in this gene are the cause of autosomal dominant Robinow syndrome. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:55465715-55490539
Strand Reverse strand
Band p14.3
Transcripts
ENST00000264634 ENSP00000264634
ENST00000474267 ENSP00000417310
ENST00000493406
ENST00000497027 ENSP00000420104
ENST00000482079 ENSP00000418184
ENST00000497817
ENST00000624674
ENST00000614415 ENSP00000478784
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 12 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005102 receptor binding
GO:0005109 frizzled binding
GO:0005110 frizzled-2 binding
GO:0005115 receptor tyrosine kinase-like orphan receptor binding
GO:0005125 cytokine activity
GO:0005515 protein binding
GO:0019904 protein domain specific binding
GO:0044212 transcription regulatory region DNA binding
GO:0048018 receptor agonist activity
Biological Process
GO:0000187 activation of MAPK activity
GO:0001667 ameboidal cell migration
GO:0001736 establishment of planar polarity
GO:0001756 somitogenesis
GO:0001837 epithelial to mesenchymal transition
GO:0001843 neural tube closure
GO:0001934 positive regulation of protein phosphorylation
GO:0001938 positive regulation of endothelial cell proliferation
GO:0001947 heart looping
GO:0002009 morphogenesis of an epithelium
GO:0002053 positive regulation of mesenchymal cell proliferation
GO:0002088 lens development in camera-type eye
GO:0002741 positive regulation of cytokine secretion involved in immune response
GO:0003323 type B pancreatic cell development
GO:0003344 pericardium morphogenesis
GO:0003401 axis elongation
GO:0003408 optic cup formation involved in camera-type eye development
GO:0006468 protein phosphorylation
GO:0007223 Wnt receptor signaling pathway, calcium modulating pathway
GO:0007254 JNK cascade
GO:0007257 activation of JUN kinase activity
GO:0007275 multicellular organismal development
GO:0007368 determination of left/right symmetry
GO:0007411 axon guidance
GO:0007442 hindgut morphogenesis
GO:0007494 midgut development
GO:0008284 positive regulation of cell proliferation
GO:0008584 male gonad development
GO:0008595 anterior/posterior axis specification, embryo
GO:0009952 anterior/posterior pattern specification
GO:0010033 response to organic substance
GO:0010595 positive regulation of endothelial cell migration
GO:0010800 positive regulation of peptidyl-threonine phosphorylation
GO:0010820 positive regulation of T cell chemotaxis
GO:0010976 positive regulation of neuron projection development
GO:0016055 Wnt signaling pathway
GO:0016477 cell migration
GO:0021891 olfactory bulb interneuron development
GO:0021915 neural tube development
GO:0030182 neuron differentiation
GO:0030216 keratinocyte differentiation
GO:0030324 lung development
GO:0030326 embryonic limb morphogenesis
GO:0030514 negative regulation of BMP signaling pathway
GO:0030825 positive regulation of cGMP metabolic process
GO:0032148 activation of protein kinase B activity
GO:0032729 positive regulation of interferon-gamma production
GO:0032755 positive regulation of interleukin-6 production
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0034613 cellular protein localization
GO:0035108 limb morphogenesis
GO:0036342 post-anal tail morphogenesis
GO:0038031 non-canonical Wnt signaling pathway via JNK cascade
GO:0040037 negative regulation of fibroblast growth factor receptor signaling pathway
GO:0042060 wound healing
GO:0042472 inner ear morphogenesis
GO:0042733 embryonic digit morphogenesis
GO:0043032 positive regulation of macrophage activation
GO:0043066 negative regulation of apoptotic process
GO:0043507 positive regulation of JUN kinase activity
GO:0045080 positive regulation of chemokine biosynthetic process
GO:0045165 cell fate commitment
GO:0045599 negative regulation of fat cell differentiation
GO:0045732 positive regulation of protein catabolic process
GO:0045766 positive regulation of angiogenesis
GO:0045778 positive regulation of ossification
GO:0045836 positive regulation of meiosis
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0046330 positive regulation of JNK cascade
GO:0046546 development of primary male sexual characteristics
GO:0048146 positive regulation of fibroblast proliferation
GO:0048546 digestive tract morphogenesis
GO:0048706 embryonic skeletal system development
GO:0048806 genitalia development
GO:0048812 neuron projection morphogenesis
GO:0048843 negative regulation of axon extension involved in axon guidance
GO:0048850 hypophysis morphogenesis
GO:0050679 positive regulation of epithelial cell proliferation
GO:0050680 negative regulation of epithelial cell proliferation
GO:0050718 positive regulation of interleukin-1 beta secretion
GO:0050729 positive regulation of inflammatory response
GO:0050919 negative chemotaxis
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051216 cartilage development
GO:0051964 negative regulation of synapse assembly
GO:0060021 palate development
GO:0060026 convergent extension
GO:0060029 convergent extension involved in organogenesis
GO:0060065 uterus development
GO:0060067 cervix development
GO:0060068 vagina development
GO:0060070 canonical Wnt signaling pathway
GO:0060071 Wnt signaling pathway, planar cell polarity pathway
GO:0060157 urinary bladder development
GO:0060324 face development
GO:0060340 positive regulation of type I interferon-mediated signaling pathway
GO:0060599 lateral sprouting involved in mammary gland duct morphogenesis
GO:0060606 tube closure
GO:0060638 mesenchymal-epithelial cell signaling
GO:0060686 negative regulation of prostatic bud formation
GO:0060744 mammary gland branching involved in thelarche
GO:0060750 epithelial cell proliferation involved in mammary gland duct elongation
GO:0060760 positive regulation of response to cytokine stimulus
GO:0060762 regulation of branching involved in mammary gland duct morphogenesis
GO:0060907 positive regulation of macrophage cytokine production
GO:0061036 positive regulation of cartilage development
GO:0061347 planar cell polarity pathway involved in outflow tract morphogenesis
GO:0061348 planar cell polarity pathway involved in ventricular septum morphogenesis
GO:0061349 planar cell polarity pathway involved in cardiac right atrium morphogenesis
GO:0061350 planar cell polarity pathway involved in cardiac muscle tissue morphogenesis
GO:0061354 planar cell polarity pathway involved in pericardium morphogenesis
GO:0070245 positive regulation of thymocyte apoptotic process
GO:0071219 cellular response to molecule of bacterial origin
GO:0071222 cellular response to lipopolysaccharide
GO:0071277 cellular response to calcium ion
GO:0071300 cellular response to retinoic acid
GO:0071346 cellular response to interferon-gamma
GO:0071425 hematopoietic stem cell proliferation
GO:0071542 dopaminergic neuron differentiation
GO:0071560 cellular response to transforming growth factor beta stimulus
GO:0072201 negative regulation of mesenchymal cell proliferation
GO:0090009 primitive streak formation
GO:0090037 positive regulation of protein kinase C signaling
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0090103 cochlea morphogenesis
GO:0090179 planar cell polarity pathway involved in neural tube closure
GO:2000049 positive regulation of cell-cell adhesion mediated by cadherin
GO:2000484 positive regulation of interleukin-8 secretion
Cellular Component
GO:0005576 extracellular region
GO:0005578 proteinaceous extracellular matrix
GO:0005615 extracellular space
GO:0005788 endoplasmic reticulum lumen
GO:0005796 Golgi lumen
GO:0005886 plasma membrane
GO:0009986 cell surface
GO:0030669 clathrin-coated endocytic vesicle membrane
GO:0031012 extracellular matrix
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
Wnt pathway
REACTOME
PCP/CE pathway pathway
Ca2+ pathway pathway
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
WNT5A-dependent internalization of FZD4 pathway
Signaling by WNT in cancer pathway
beta-catenin independent WNT signaling pathway
Signaling by Wnt pathway
Signaling by GPCR pathway
WNT ligand secretion is abrogated by the PORCN inhibitor LGK974 pathway
Signal Transduction pathway
WNT ligand biogenesis and trafficking pathway
negative regulation of TCF-dependent signaling by WNT ligand antagonists pathway
TCF dependent signaling in response to WNT pathway
Asymmetric localization of PCP proteins pathway
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 pathway
RNF mutants show enhanced WNT signaling and proliferation pathway
GPCR ligand binding pathway
XAV939 inhibits tankyrase, stabilizing AXIN pathway
Class B/2 (Secretin family receptors) pathway
Disease pathway
KEGG
Wnt signaling pathway pathway
Hedgehog signaling pathway pathway
Melanogenesis pathway
Pathways in cancer pathway
Basal cell carcinoma pathway
INOH
GPCR signaling pathway
Wnt signaling pathway pathway
PID BIOCARTA
PID NCI
Wnt signaling network
Validated targets of C-MYC transcriptional repression
Noncanonical Wnt signaling pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.603906 Hs.613961 Hs.643085 Hs.723431
RefSeq NM_001256105 NM_003392 XM_006713324
HUGO
OMIM
CCDS CCDS46850 CCDS58835
HPRD 01293
IMGT
EMBL
GenPept
RNA Seq Atlas