Version 5.4
Homo sapiens Protein: WNT5A
Summary
InnateDB Protein IDBP-485200.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol WNT5A
Protein Name wingless-type MMTV integration site family, member 5A
Synonyms hWNT5A;
Species Homo sapiens
Ensembl Protein ENSP00000417310
InnateDB Gene IDBG-40713 (WNT5A)
Protein Structure
UniProt Annotation
Function Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. In the presence of FZD4, activates beta-catenin signaling. In the presence of ROR2, inhibits the canonical Wnt pathway by promoting beta-catenin degradation through a GSK3-independent pathway which involves down-regulation of beta-catenin-induced reporter gene expression. Suppression of the canonical pathway allows chondrogenesis to occur and inhibits tumor formation. Stimulates cell migration. Decreases proliferation, migration, invasiveness and clonogenicity of carcinoma cells and may act as a tumor suppressor. Mediates motility of melanoma cells. Required during embryogenesis for extension of the primary anterior-posterior axis and for outgrowth of limbs and the genital tubercle. Inhibits type II collagen expression in chondrocytes. {ECO:0000269PubMed:15735754, ECO:0000269PubMed:17426020}.
Subcellular Localization Secreted, extracellular space, extracellular matrix.
Disease Associations Robinow syndrome autosomal dominant (DRS) [MIM:180700]: A disease characterized by short-limb dwarfism, costovertebral segmentation defects and abnormalities of the head, face and external genitalia. The clinical signs are generally milder in dominant cases. {ECO:0000269PubMed:19918918}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Tissue Specificity Expression is increased in differentiated thyroid carcinomas compared to normal thyroid tissue and anaplastic thyroid tumors where expression is low or undetectable. Expression is found in thyrocytes but not in stromal cells (at protein level). {ECO:0000269PubMed:15735754}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 12 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005102 receptor binding
GO:0005109 frizzled binding
GO:0005115 receptor tyrosine kinase-like orphan receptor binding
GO:0044212 transcription regulatory region DNA binding
GO:0048018 receptor agonist activity
Biological Process
GO:0000187 activation of MAPK activity
GO:0001837 epithelial to mesenchymal transition
GO:0001938 positive regulation of endothelial cell proliferation
GO:0002088 lens development in camera-type eye
GO:0002741 positive regulation of cytokine secretion involved in immune response
GO:0003408 optic cup formation involved in camera-type eye development
GO:0007223 Wnt receptor signaling pathway, calcium modulating pathway
GO:0007257 activation of JUN kinase activity
GO:0007275 multicellular organismal development
GO:0007411 axon guidance
GO:0008584 male gonad development
GO:0010033 response to organic substance
GO:0010595 positive regulation of endothelial cell migration
GO:0010820 positive regulation of T cell chemotaxis
GO:0010976 positive regulation of neuron projection development
GO:0016055 Wnt signaling pathway
GO:0021891 olfactory bulb interneuron development
GO:0030182 neuron differentiation
GO:0030216 keratinocyte differentiation
GO:0030825 positive regulation of cGMP metabolic process
GO:0032148 activation of protein kinase B activity
GO:0032755 positive regulation of interleukin-6 production
GO:0034613 cellular protein localization
GO:0042060 wound healing
GO:0043032 positive regulation of macrophage activation
GO:0043066 negative regulation of apoptotic process
GO:0045080 positive regulation of chemokine biosynthetic process
GO:0045165 cell fate commitment
GO:0045599 negative regulation of fat cell differentiation
GO:0045732 positive regulation of protein catabolic process
GO:0045766 positive regulation of angiogenesis
GO:0045778 positive regulation of ossification
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048146 positive regulation of fibroblast proliferation
GO:0048706 embryonic skeletal system development
GO:0048806 genitalia development
GO:0050718 positive regulation of interleukin-1 beta secretion
GO:0050729 positive regulation of inflammatory response
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051216 cartilage development
GO:0060021 palate development
GO:0060324 face development
GO:0060340 positive regulation of type I interferon-mediated signaling pathway
GO:0060760 positive regulation of response to cytokine stimulus
GO:0060907 positive regulation of macrophage cytokine production
GO:0071222 cellular response to lipopolysaccharide
GO:0071277 cellular response to calcium ion
GO:0071300 cellular response to retinoic acid
GO:0071346 cellular response to interferon-gamma
GO:0071425 hematopoietic stem cell proliferation
GO:0071560 cellular response to transforming growth factor beta stimulus
GO:0072201 negative regulation of mesenchymal cell proliferation
GO:0090037 positive regulation of protein kinase C signaling
GO:0090090 negative regulation of canonical Wnt signaling pathway
Cellular Component
GO:0005576 extracellular region
GO:0005578 proteinaceous extracellular matrix
GO:0005615 extracellular space
GO:0005788 endoplasmic reticulum lumen
GO:0005796 Golgi lumen
GO:0005886 plasma membrane
GO:0030669 clathrin-coated endocytic vesicle membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR005817 Wnt
PFAM PF00110
PRINTS PR01349
PIRSF
SMART SM00097
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P41221
PhosphoSite PhosphoSite-P41221
TrEMBL A0A024R316
UniProt Splice Variant
Entrez Gene 7474
UniGene Hs.723431
RefSeq
HUGO HGNC:12784
OMIM 164975
CCDS CCDS46850
HPRD 01293
IMGT
EMBL AK290375 AK290869 BC064694 CH471055 L20861
GenPept AAA16842 AAH64694 BAF83064 BAF83558 EAW65310 EAW65311

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca