Homo sapiens Gene: INMT
Summary
InnateDB Gene IDBG-407426.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol INMT
Gene Name indolethylamine N-methyltransferase
Synonyms TEMT;
Species Homo sapiens
Ensembl Gene ENSG00000241644
Encoded Proteins
indolethylamine N-methyltransferase
indolethylamine N-methyltransferase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary N-methylation of endogenous and xenobiotic compounds is a major method by which they are degraded. This gene encodes an enzyme that N-methylates indoles such as tryptamine. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the downstream FAM188B (family with sequence similarity 188, member B) gene. [provided by RefSeq, Nov 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:30697985-30757602
Strand Forward strand
Band p14.3
Transcripts
ENST00000013222 ENSP00000013222
ENST00000409539 ENSP00000386961
ENST00000484180
ENST00000461246
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004790 thioether S-methyltransferase activity
GO:0008168 methyltransferase activity
GO:0030748 amine N-methyltransferase activity
Biological Process
GO:0009308 amine metabolic process
GO:0009636 response to toxic substance
GO:0032259 methylation
Cellular Component
GO:0005829 cytosol
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
KEGG
Tryptophan metabolism pathway
Selenocompound metabolism pathway
INOH
Tryptophan degradation pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt O95050
TrEMBL Q3MIB5
UniProt Splice Variant
Entrez Gene 11185
UniGene Hs.619219 Hs.632629
RefSeq NM_001199219 NM_006774
HUGO HGNC:6069
OMIM 604854
CCDS CCDS5430 CCDS56479
HPRD
IMGT
EMBL AB041362 AC004976 AC006022 AF128846 AF128847 AF128848 AK313832 BC033813 BC103712 BC106902 BC106903
GenPept AAD04723 AAF18304 AAF18305 AAF18306 AAH33813 AAI03713 AAI06903 AAI06904 BAA94451
RNA Seq Atlas 11185