Homo sapiens Gene: CCL1
Summary
InnateDB Gene IDBG-40784.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CCL1
Gene Name chemokine (C-C motif) ligand 1
Synonyms I-309; P500; SCYA1; SISe; TCA3;
Species Homo sapiens
Ensembl Gene ENSG00000108702
Encoded Proteins
chemokine (C-C motif) ligand 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
The JAK2/STAT5/CIS pathway suppresses CCL1 but not CCL7 and CCL8 chemokine expression
CCL1 secretion in freshly isolated monocytes is induced by the combined engagement of TLR3/TLR4/TLR8. As monocytes differentiate, the capacity to induce CCL1 is lost via a IL23-dependent mechanism.
Entrez Gene
Summary This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The protein encoded by this gene is structurally related to the CXC subfamily of cytokines. Members of this subfamily are characterized by two cysteines separated by a single amino acid. This cytokine is secreted by activated T cells and displays chemotactic activity for monocytes but not for neutrophils. It binds to the chemokine receptor CCR8. [provided by RefSeq, Jul 2008]
This antimicrobial gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, is secreted by activated T cells and displays chemotactic activity for monocytes but not for neutrophils. It binds to the chemokine (C-C motif) receptor 8. [provided by RefSeq, Sep 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:34360328-34363231
Strand Reverse strand
Band q12
Transcripts
ENST00000225842 ENSP00000225842
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 2 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005125 cytokine activity
GO:0005515 protein binding
GO:0008009 chemokine activity
Biological Process
GO:0006874 cellular calcium ion homeostasis
GO:0006935 chemotaxis
GO:0006955 immune response
GO:0007165 signal transduction
GO:0016032 viral process
GO:0045087 innate immune response (InnateDB)
GO:0060326 cell chemotaxis
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
KEGG
Cytokine-cytokine receptor interaction pathway
Chemokine signaling pathway pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt P22362
TrEMBL Q76BR7
UniProt Splice Variant
Entrez Gene 6346
UniGene Hs.72918
RefSeq NM_002981
HUGO HGNC:10609
OMIM 182281
CCDS CCDS11282
HPRD 01654
IMGT
EMBL AB110829 AK312183 BC105073 BC105075 CH471147 M57502 M57506
GenPept AAA52705 AAA61196 AAI05074 AAI05076 BAC98367 BAG35116 EAW80204
RNA Seq Atlas 6346