Homo sapiens Gene: ARFGAP3
Summary
InnateDB Gene IDBG-408807.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ARFGAP3
Gene Name ADP-ribosylation factor GTPase activating protein 3
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000242247
Encoded Proteins
ADP-ribosylation factor GTPase activating protein 3
ADP-ribosylation factor GTPase activating protein 3
ADP-ribosylation factor GTPase activating protein 3
ADP-ribosylation factor GTPase activating protein 3
ADP-ribosylation factor GTPase activating protein 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a GTPase-activating protein (GAP) that associates with the Golgi apparatus and regulates the early secretory pathway of proteins. The encoded protein promotes hydrolysis of ADP-ribosylation factor 1 (ARF1)-bound GTP, which is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles. Dissociation of the coat proteins is a prerequisite for the fusion of these vesicles with target compartments. The activity of this protein is sensitive to phospholipids. Multiple transcript variants encoding different isoforms have been found for this gene. This gene was originally known as ARFGAP1, but that is now the name of a related but different gene. [provided by RefSeq, Nov 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 22:42796502-42858106
Strand Reverse strand
Band q13.2
Transcripts
ENST00000263245 ENSP00000263245
ENST00000437119 ENSP00000388791
ENST00000453516 ENSP00000403995
ENST00000454099 ENSP00000403520
ENST00000435208 ENSP00000407734
ENST00000493606
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008060 ARF GTPase activator activity
GO:0008270 zinc ion binding
GO:0008565 protein transporter activity
Biological Process
GO:0006886 intracellular protein transport
GO:0009306 protein secretion
GO:0016192 vesicle-mediated transport
GO:0032312 regulation of ARF GTPase activity
GO:0043547 positive regulation of GTPase activity
Cellular Component
GO:0000139 Golgi membrane
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
Endocytosis pathway
INOH
PID BIOCARTA
Adp-ribosylation factor [Biocarta view]
Rho cell motility signaling pathway [Biocarta view]
Rac1 cell motility signaling pathway [Biocarta view]
T cell receptor signaling pathway [Biocarta view]
PID NCI
Cross-References
SwissProt Q9NP61
TrEMBL A0A024R4U0
UniProt Splice Variant
Entrez Gene 26286
UniGene Hs.685225 Hs.722463
RefSeq NM_014570 NM_001142293
HUGO HGNC:661
OMIM 612439
CCDS CCDS14042 CCDS46722
HPRD 06444
IMGT
EMBL AF111847 AK002083 AK022768 AL049757 AL049758 AL137598 AL159143 BC005122 CH471138 CR456382
GenPept AAF40310 AAH05122 BAA92076 BAB14236 CAB70834 CAB76901 CAG30268 CAI20950 CAI21510 EAW73275 EAW73276
RNA Seq Atlas 26286