Version 5.4
Homo sapiens Gene: LIG3
Summary
InnateDB Gene IDBG-40894.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LIG3
Gene Name ligase III, DNA, ATP-dependent
Synonyms LIG2
Species Homo sapiens
Ensembl Gene ENSG00000005156
Encoded Proteins
IDBP-40896
ligase III, DNA, ATP-dependent
IDBP-40900
ligase III, DNA, ATP-dependent
IDBP-764293
IDBP-758515
IDBP-762158
IDBP-764493
IDBP-760441
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of the DNA ligase family. Each member of this family encodes a protein that catalyzes the joining of DNA ends but they each have a distinct role in DNA metabolism. The protein encoded by this gene is involved in excision repair and is located in both the mitochondria and nucleus, with translation initiation from the upstream start codon allowing for transport to the mitochondria and translation initiation from a downstream start codon allowing for transport to the nucleus. Additionally, alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:34980494-35009743
Strand Forward strand
Band q12
Transcripts
ENST00000378526 ENSP00000367787
ENST00000262327 ENSP00000262327
ENST00000586435
ENST00000593099
ENST00000592690 ENSP00000467063
ENST00000585941 ENSP00000468479
ENST00000585740 ENSP00000467757
ENST00000592244
ENST00000586407
ENST00000585370 ENSP00000465288
ENST00000588713
ENST00000586058
ENST00000586119
ENST00000590181
ENST00000588109 ENSP00000466278
ENST00000590630
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 29 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 29 [view]
Protein-Protein 29 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003909 DNA ligase activity
GO:0003910 DNA ligase (ATP) activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008270 zinc ion binding
Biological Process
GO:0006273 lagging strand elongation
GO:0006281 DNA repair
GO:0006284 base-excision repair
GO:0006288 base-excision repair, DNA ligation
GO:0006289 nucleotide-excision repair
GO:0006303 double-strand break repair via nonhomologous end joining
GO:0006310 DNA recombination
GO:0007131 reciprocal meiotic recombination
GO:0007283 spermatogenesis
GO:0043504 mitochondrial DNA repair
GO:0045910 negative regulation of DNA recombination
GO:0051103 DNA ligation involved in DNA repair
GO:0071897 DNA biosynthetic process
Cellular Component
GO:0000794 condensed nuclear chromosome
GO:0000795 synaptonemal complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005694 chromosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000020697
View Gene Order
ENSBTAG00000018689
Not yet available
Pathways
NETPATH
REACTOME
REACT_933
Resolution of AP sites via the single-nucleotide replacement pathway pathway
REACT_1893
Resolution of Abasic Sites (AP sites) pathway
REACT_1104
Base Excision Repair pathway
REACT_216
DNA Repair pathway
KEGG
hsa03410
Base excision repair pathway
INOH
PID NCI
Cross-References
SwissProt P49916
TrEMBL B7Z6I3 C4B7Q3 E5KLB5 K7ENR9 K7EQB6
UniProt Splice Variant
Entrez Gene 3980
UniGene Hs.100299
RefSeq NM_013975 XM_005257970 XM_005257971 NM_002311 XM_006721896
HUGO HGNC:6600
OMIM 600940
CCDS CCDS11284 CCDS11285
HPRD 02966
IMGT
EMBL AB470625 AC004223 AC022903 AF491645 AK300363 BC068005 CH471147 HQ204826 HQ204827 HQ204828 HQ204829 HQ204830 HQ204831 HQ204832 HQ204833 HQ204834 HQ204835 HQ204836 HQ204837 HQ204838 HQ204839 HQ204840 HQ204841 HQ204842 HQ204843 HQ204844 HQ204845 HQ204846 HQ204847 HQ204848 HQ204849 HQ204850 HQ204851 HQ204852 HQ204853 HQ204854 HQ204855 HQ204856 HQ204857 HQ204858 HQ204859 HQ204860 HQ204861 HQ204862 HQ204863 HQ204864 HQ204865 U40671 X84740
GenPept AAA85022 AAH68005 AAL91592 ADP89974 ADP89976 ADP89978 ADP89980 ADP89982 ADP89984 ADP89986 ADP89988 ADP89990 ADP89992 ADP89994 ADP89996 ADP89998 ADP90000 ADP90002 ADP90004 ADP90006 ADP90008 ADP90010 ADP90012 ADP90014 ADP90016 ADP90018 ADP90020 ADP90022 ADP90024 ADP90026 ADP90028 ADP90030 ADP90032 ADP90034 ADP90036 ADP90038 ADP90040 ADP90042 ADP90044 ADP90046 ADP90048 ADP90050 ADP90052 BAH13269 BAH59593 CAA59230 EAW80199
RNA Seq Atlas 3980

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca