InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: LIG3

Summary

InnateDB Protein

IDBP-40896.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LIG3

Protein Name

ligase III, DNA, ATP-dependent

Synonyms

LIG2;

Species

Homo sapiens

Ensembl Protein

ENSP00000367787

InnateDB Gene

IDBG-40894 (LIG3)

Protein Structure

UniProt Annotation

Function

Interacts with DNA-repair protein XRCC1 and can correct defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Testis, thymus, prostate and heart.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 29 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	29 [view]
Protein-Protein	29 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003909	DNA ligase activity
GO:0003910	DNA ligase (ATP) activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008270	zinc ion binding

Biological Process

GO:0006273	lagging strand elongation
GO:0006281	DNA repair
GO:0006284	base-excision repair
GO:0006288	base-excision repair, DNA ligation
GO:0006289	nucleotide-excision repair
GO:0006303	double-strand break repair via nonhomologous end joining
GO:0006310	DNA recombination
GO:0007131	reciprocal meiotic recombination
GO:0007283	spermatogenesis
GO:0043504	mitochondrial DNA repair
GO:0045910	negative regulation of DNA recombination
GO:0071897	DNA biosynthetic process

Cellular Component

GO:0000794	condensed nuclear chromosome
GO:0000795	synaptonemal complex
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005694	chromosome

Protein Structure and Domains

PDB ID

InterPro

IPR000977 DNA ligase, ATP-dependent
IPR001357 BRCT domain
IPR001510 Zinc finger, PARP-type
IPR012308 DNA ligase, ATP-dependent, N-terminal
IPR012309 DNA ligase, ATP-dependent, C-terminal
IPR012310 DNA ligase, ATP-dependent, central
IPR012340 Nucleic acid-binding, OB-fold

PFAM

PF00533
PF12738
PF00645
PF04675
PF04679
PF01068

PRINTS

PIRSF

SMART

SM00292

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P49916