Homo sapiens Gene: CDC2L1
Summary
InnateDB Gene IDBG-409201.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CDC2L1
Gene Name cyclin-dependent kinase 11B
Synonyms CDC2L1; CDK11; CDK11-p110; CDK11-p46; CDK11-p58; CLK-1; p58; p58CDC2L1; p58CLK-1; PITSLREA; PK58;
Species Homo sapiens
Ensembl Gene ENSG00000248333
Encoded Proteins
cyclin-dependent kinase 11B
cyclin-dependent kinase 11B
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the p34Cdc2 protein kinase family. p34Cdc2 kinase family members are known to be essential for eukaryotic cell cycle control. This gene is in close proximity to CDC2L2, a nearly identical gene in the same chromosomal region. The gene loci including this gene, CDC2L2, as well as metalloprotease MMP21/22, consist of two identical, tandemly linked genomic regions which are thought to be a part of the larger region that has been duplicated. This gene and CDC2L2 were shown to be deleted or altered frequently in neuroblastoma with amplified MYCN genes. The protein kinase encoded by this gene could be cleaved by caspases and was demonstrated to play roles in cell apoptosis. Several alternatively spliced variants of this gene have been reported. [provided by RefSeq, Jul 2008]
This gene encodes a member of the serine/threonine protein kinase family. Members of this kinase family are known to be essential for eukaryotic cell cycle control. Due to a segmental duplication, this gene shares very high sequence identity with a neighboring gene. These two genes are frequently deleted or altered in neuroblastoma. The protein kinase encoded by this gene can be cleaved by caspases and may play a role in cell apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:1635227-1722818
Strand Reverse strand
Band p36.33
Transcripts
ENST00000340677 ENSP00000464016
ENST00000341832 ENSP00000463048
ENST00000341028
ENST00000317673 ENSP00000463200
ENST00000407249 ENSP00000464036
ENST00000615951 ENSP00000481846
ENST00000611150 ENSP00000484222
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 41 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 41 [view]
Protein-Protein 41 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
Biological Process
GO:0006468 protein phosphorylation
Cellular Component
Orthologs
Species
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
Low
Tentative data, uncurated. RBBH derived.
Cross-References
SwissProt
TrEMBL Q5QPQ9 X6R529
UniProt Splice Variant
Entrez Gene 984
UniGene
RefSeq NM_001787 NM_033486 NM_033487 NM_033488 NM_033489 NM_033490 NM_033492 NM_033493 XM_006711061 XM_006711062 XM_006711063
HUGO HGNC:1729
OMIM 116951 176873
CCDS CCDS72682 CCDS72683 CCDS72684
HPRD
IMGT
EMBL AL031282 AL691432
GenPept
RNA Seq Atlas 728642 984