Mus musculus Gene: Cdk11b
Summary
InnateDB Gene IDBG-207702.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cdk11b
Gene Name cyclin-dependent kinase 11B
Synonyms AA989746; Cdc11b; Cdc2l1; Cdc2l2; Cdk11; CDK11-p110; CDK11-p46; CDK11-p58; p58;
Species Mus musculus
Ensembl Gene ENSMUSG00000029062
Encoded Proteins
cyclin-dependent kinase 11B
cyclin-dependent kinase 11B
cyclin-dependent kinase 11B
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000248333:
This gene encodes a member of the p34Cdc2 protein kinase family. p34Cdc2 kinase family members are known to be essential for eukaryotic cell cycle control. This gene is in close proximity to CDC2L2, a nearly identical gene in the same chromosomal region. The gene loci including this gene, CDC2L2, as well as metalloprotease MMP21/22, consist of two identical, tandemly linked genomic regions which are thought to be a part of the larger region that has been duplicated. This gene and CDC2L2 were shown to be deleted or altered frequently in neuroblastoma with amplified MYCN genes. The protein kinase encoded by this gene could be cleaved by caspases and was demonstrated to play roles in cell apoptosis. Several alternatively spliced variants of this gene have been reported. [provided by RefSeq, Jul 2008]
This gene encodes a member of the serine/threonine protein kinase family. Members of this kinase family are known to be essential for eukaryotic cell cycle control. Due to a segmental duplication, this gene shares very high sequence identity with a neighboring gene. These two genes are frequently deleted or altered in neuroblastoma. The protein kinase encoded by this gene can be cleaved by caspases and may play a role in cell apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:155624854-155649938
Strand Forward strand
Band E2
Transcripts
ENSMUST00000067081 ENSMUSP00000070527
ENSMUST00000105600 ENSMUSP00000101225
ENSMUST00000105598 ENSMUSP00000101223
ENSMUST00000135550
ENSMUST00000149498
ENSMUST00000142513
ENSMUST00000155100
ENSMUST00000143196
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004693 cyclin-dependent protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
Biological Process
GO:0001824 blastocyst development
GO:0006468 protein phosphorylation
GO:0007049 cell cycle
GO:0007088 regulation of mitosis
GO:2001234 negative regulation of apoptotic signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
Orthologs
Species
Homo sapiens
Gene ID
Gene Order
Method
Confidence
Comments
Low
Tentative data, uncurated. RBBH derived.
Pathways
NETPATH
REACTOME
Transcriptional regulation of white adipocyte differentiation pathway
Mus musculus biological processes pathway
Developmental Biology pathway
Transcriptional Regulation of Adipocyte Differentiation in 3T3-L1 Pre-adipocytes pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.267410
RefSeq NM_007661 XM_006538507 XM_006538509 XM_006538510 XM_006538511 XM_006538513
OMIM
CCDS CCDS19033
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas