Version 5.4
Homo sapiens Gene: NME1-NME2
Summary
InnateDB Gene IDBG-409288.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NME1-NME2
Gene Name NME1-NME2 readthrough
Synonyms NDKB; NDPK-B; NDPKB; NM23-H2; NM23B; PUF
Species Homo sapiens
Ensembl Gene ENSG00000243678
Encoded Proteins
IDBP-244105
non-metastatic cells 2, protein (NM23B) expressed in
IDBP-478556
non-metastatic cells 2, protein (NM23B) expressed in
IDBP-475081
non-metastatic cells 2, protein (NM23B) expressed in
IDBP-483149
non-metastatic cells 2, protein (NM23B) expressed in
IDBP-473700
non-metastatic cells 2, protein (NM23B) expressed in
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by NME1) and 'B' (encoded by this gene) isoforms. Multiple alternatively spliced transcript variants have been found for this gene. Read-through transcription from the neighboring upstream gene (NME1) generates naturally-occurring transcripts (NME1-NME2) that encode a fusion protein comprised of sequence sharing identity with each individual gene product. [provided by RefSeq, Nov 2010]
Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of \'A\' (encoded by NME1) and \'B\' (encoded by this gene) isoforms. Multiple alternatively spliced transcript variants have been found for this gene. Read-through transcription from the neighboring upstream gene (NME1) generates naturally-occurring transcripts (NME1-NME2) that encode a fusion protein comprised of sequence sharing identity with each individual gene product. [provided by RefSeq, Nov 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:51165435-51171747
Strand Forward strand
Band q21.33
Transcripts
ENST00000393190 ENSP00000376886
ENST00000514264 ENSP00000426976
ENST00000513177 ENSP00000425581
ENST00000512737 ENSP00000421064
ENST00000503064 ENSP00000426901
ENST00000485076
ENST00000573262
ENST00000570801
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 52 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 52 [view]
Protein-Protein 52 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0004550 nucleoside diphosphate kinase activity
GO:0004673 protein histidine kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005504 fatty acid binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008144 drug binding
GO:0019215 intermediate filament binding
GO:0019899 enzyme binding
GO:0046872 metal ion binding
Biological Process
GO:0002762 negative regulation of myeloid leukocyte differentiation
GO:0006165 nucleoside diphosphate phosphorylation
GO:0006183 GTP biosynthetic process
GO:0006228 UTP biosynthetic process
GO:0006241 CTP biosynthetic process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007155 cell adhesion
GO:0007229 integrin-mediated signaling pathway
GO:0009142 nucleoside triphosphate biosynthetic process
GO:0010976 positive regulation of neuron projection development
GO:0015949 nucleobase-containing small molecule interconversion
GO:0018106 peptidyl-histidine phosphorylation
GO:0030819 positive regulation of cAMP biosynthetic process
GO:0034599 cellular response to oxidative stress
GO:0043066 negative regulation of apoptotic process
GO:0044281 small molecule metabolic process
GO:0045618 positive regulation of keratinocyte differentiation
GO:0045682 regulation of epidermis development
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0046777 protein autophosphorylation
GO:0050679 positive regulation of epithelial cell proliferation
GO:0051259 protein oligomerization
GO:0055086 nucleobase-containing small molecule metabolic process
GO:0060416 response to growth hormone
GO:0071333 cellular response to glucose stimulus
GO:0071398 cellular response to fatty acid
Cellular Component
GO:0001726 ruffle
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005882 intermediate filament
GO:0030027 lamellipodium
GO:0031966 mitochondrial membrane
GO:0048471 perinuclear region of cytoplasm
GO:0070062 extracellular vesicular exosome
GO:0071944 cell periphery
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000020857
View Gene Order
Pathways
NETPATH
REACTOME
KEGG
hsa00240
Pyrimidine metabolism pathway
hsa00230
Purine metabolism pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL F6XY72 Q6FHN3
UniProt Splice Variant
Entrez Gene 4831
UniGene
RefSeq NM_001018139 NM_001018137 NM_001018138 NM_001198682 NM_002512
HUGO HGNC:33531
OMIM 156491
CCDS CCDS11580 CCDS74107
HPRD 01132
IMGT
EMBL AC005839 AK313448 BC002476 BC095458 BC133029 BC133031 BT007045 CH471109 CR541718 DQ109675 EU794639 L16785 M36981 U29200 X58965
GenPept AAA36369 AAA60228 AAA86745 AAH02476 AAH95458 AAI33030 AAI33032 AAP35694 AAZ82097 ACJ13693 BAG36237 CAB37870 CAG46519 EAW94564 EAW94567
RNA Seq Atlas 4831

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca