InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NME1-NME2

Summary

InnateDB Protein

IDBP-244105.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NME1-NME2

Protein Name

non-metastatic cells 2, protein (NM23B) expressed in

Synonyms

NDKB; NDPK-B; NDPKB; NM23-H2; NM23B; PUF;

Species

Homo sapiens

Ensembl Protein

ENSP00000376886

InnateDB Gene

IDBG-409288 (NME1-NME2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 52 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	52 [view]
Protein-Protein	52 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0004550	nucleoside diphosphate kinase activity
GO:0004673	protein histidine kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0005504	fatty acid binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008144	drug binding
GO:0019215	intermediate filament binding
GO:0019899	enzyme binding
GO:0046872	metal ion binding

Biological Process

GO:0002762	negative regulation of myeloid leukocyte differentiation
GO:0006165	nucleoside diphosphate phosphorylation
GO:0006183	GTP biosynthetic process
GO:0006228	UTP biosynthetic process
GO:0006241	CTP biosynthetic process
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007155	cell adhesion
GO:0007229	integrin-mediated signaling pathway
GO:0009142	nucleoside triphosphate biosynthetic process
GO:0010976	positive regulation of neuron projection development
GO:0015949	nucleobase-containing small molecule interconversion
GO:0018106	peptidyl-histidine phosphorylation
GO:0030819	positive regulation of cAMP biosynthetic process
GO:0034599	cellular response to oxidative stress
GO:0043066	negative regulation of apoptotic process
GO:0044281	small molecule metabolic process
GO:0045618	positive regulation of keratinocyte differentiation
GO:0045682	regulation of epidermis development
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046777	protein autophosphorylation
GO:0050679	positive regulation of epithelial cell proliferation
GO:0051259	protein oligomerization
GO:0055086	nucleobase-containing small molecule metabolic process
GO:0060416	response to growth hormone
GO:0071333	cellular response to glucose stimulus
GO:0071398	cellular response to fatty acid

Cellular Component

GO:0001726	ruffle
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005882	intermediate filament
GO:0030027	lamellipodium
GO:0031966	mitochondrial membrane
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular vesicular exosome
GO:0071944	cell periphery