Version 5.4
| Homo sapiens Gene: ARPC1A | |||||||||||||||||||
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| Summary | |||||||||||||||||||
| InnateDB Gene | IDBG-409339.3 | ||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
| Gene Symbol | ARPC1A | ||||||||||||||||||
| Gene Name | actin related protein 2/3 complex, subunit 1A, 41kDa | ||||||||||||||||||
| Synonyms | Arc40; HEL-68; SOP2Hs; SOP2L | ||||||||||||||||||
| Species | Homo sapiens | ||||||||||||||||||
| Ensembl Gene | ENSG00000241685 | ||||||||||||||||||
| Encoded Proteins |
actin related protein 2/3 complex, subunit 1A, 41kDa
actin related protein 2/3 complex, subunit 1A, 41kDa
actin related protein 2/3 complex, subunit 1A, 41kDa
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| Protein Structure | |||||||||||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
| Entrez Gene | |||||||||||||||||||
| Summary |
This gene encodes one of seven subunits of the human Arp2/3 protein complex. This subunit is a member of the SOP2 family of proteins and is most similar to the protein encoded by gene ARPC1B. The similarity between these two proteins suggests that they both may function as p41 subunit of the human Arp2/3 complex that has been implicated in the control of actin polymerization in cells. It is possible that the p41 subunit is involved in assembling and maintaining the structure of the Arp2/3 complex. Multiple versions of the p41 subunit may adapt the functions of the complex to different cell types or developmental stages. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010] |
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| Gene Information | |||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||
| Genomic Location | Chromosome 7:99325898-99388164 | ||||||||||||||||||
| Strand | Forward strand | ||||||||||||||||||
| Band | q22.1 | ||||||||||||||||||
| Transcripts |
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| Interactions | |||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 28 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||
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Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathways | |||||||||||||||||||
| NETPATH | |||||||||||||||||||
| REACTOME |
Regulation of actin dynamics for phagocytic cup formation pathway
Developmental Biology pathway
EPHB-mediated forward signaling pathway
Innate Immune System pathway
Axon guidance pathway
Immune System pathway
Fcgamma receptor (FCGR) dependent phagocytosis pathway
EPH-Ephrin signaling pathway
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| KEGG |
Regulation of actin cytoskeleton pathway
Pathogenic Escherichia coli infection pathway
Fc gamma R-mediated phagocytosis pathway
Bacterial invasion of epithelial cells pathway
Shigellosis pathway
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| INOH | |||||||||||||||||||
| PID NCI | |||||||||||||||||||
| Cross-References | |||||||||||||||||||
| SwissProt | |||||||||||||||||||
| TrEMBL | |||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||
| Entrez Gene | |||||||||||||||||||
| UniGene | Hs.124126 Hs.634860 | ||||||||||||||||||
| RefSeq | NM_001190996 NM_006409 | ||||||||||||||||||
| HUGO | |||||||||||||||||||
| OMIM | |||||||||||||||||||
| CCDS | CCDS5660 | ||||||||||||||||||
| HPRD | 07252 | ||||||||||||||||||
| IMGT | |||||||||||||||||||
| EMBL | |||||||||||||||||||
| GenPept | |||||||||||||||||||
| RNA Seq Atlas | |||||||||||||||||||