InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ARPC1A

Summary

InnateDB Protein

IDBP-29025.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ARPC1A

Protein Name

actin related protein 2/3 complex, subunit 1A, 41kDa

Synonyms

Arc40; HEL-68; SOP2Hs; SOP2L;

Species

Homo sapiens

Ensembl Protein

ENSP00000262942

InnateDB Gene

IDBG-409339 (ARPC1A)

Protein Structure

UniProt Annotation

Function

Probably functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.

Subcellular Localization

Cytoplasm, cytoskeleton {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 28 experimentally validated interaction(s) in this database.

Experimentally validated
Total	28 [view]
Protein-Protein	27 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005515	protein binding

Biological Process

GO:0030036	actin cytoskeleton organization
GO:0030833	regulation of actin filament polymerization
GO:0034314	Arp2/3 complex-mediated actin nucleation
GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0045087	innate immune response

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005856	cytoskeleton
GO:0005885	Arp2/3 protein complex
GO:0015629	actin cytoskeleton
GO:0070062	extracellular vesicular exosome