Homo sapiens Gene: ATP5J2
Summary
InnateDB Gene IDBG-409428.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ATP5J2
Gene Name ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F2
Synonyms ATP5JL;
Species Homo sapiens
Ensembl Gene ENSG00000241468
Encoded Proteins
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F2
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F2
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F2
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F2
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F2
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F2
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. It is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, which comprises the proton channel. The catalytic portion of mitochondrial ATP synthase consists of five different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and single representatives of the gamma, delta, and epsilon subunits. The proton channel likely has nine subunits (a, b, c, d, e, f, g, F6 and 8). This gene encodes the f subunit of the Fo complex. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. This gene has multiple pseudogenes. Naturally occurring read-through transcription also exists between this gene and the downstream pentatricopeptide repeat domain 1 (PTCD1) gene. [provided by RefSeq, Nov 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:99448475-99466331
Strand Reverse strand
Band q22.1
Transcripts
ENST00000292475 ENSP00000292475
ENST00000359832 ENSP00000352890
ENST00000394186 ENSP00000377740
ENST00000414062 ENSP00000412149
ENST00000449683 ENSP00000407540
ENST00000466753
ENST00000491560
ENST00000488775 ENSP00000418197
ENST00000481899
ENST00000523680 ENSP00000430398
ENST00000485011
ENST00000524321
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
Experimentally validated
Total 24 [view]
Protein-Protein 23 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0016887 ATPase activity
GO:0022857 transmembrane transporter activity
Biological Process
GO:0006200 ATP catabolic process
GO:0015992 proton transport
GO:0022904 respiratory electron transport chain
GO:0042776 mitochondrial ATP synthesis coupled proton transport
GO:0044237 cellular metabolic process
GO:0044281 small molecule metabolic process
Cellular Component
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005753 mitochondrial proton-transporting ATP synthase complex
GO:0016021 integral component of membrane
GO:0045263 proton-transporting ATP synthase complex, coupling factor F(o)
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. pathway
Formation of ATP by chemiosmotic coupling pathway
The citric acid (TCA) cycle and respiratory electron transport pathway
Metabolism pathway
KEGG
Oxidative phosphorylation pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.521056 Hs.710672
RefSeq NM_001003713 NM_001003714 NM_001039178 NM_004889
HUGO
OMIM
CCDS CCDS34692 CCDS47653 CCDS47654 CCDS5665
HPRD 16520
IMGT
EMBL
GenPept
RNA Seq Atlas