Homo sapiens Gene: UGT1A8
Summary
InnateDB Gene IDBG-409444.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol UGT1A8
Gene Name UDP glucuronosyltransferase 1 family, polypeptide A8
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000242366
Encoded Proteins
UDP glucuronosyltransferase 1 family, polypeptide A8
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene has glucuronidase activity with many substrates including coumarins, phenols, anthraquinones, flavones, and some opioids. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:233617645-233773310
Strand Forward strand
Band q37.1
Transcripts
ENST00000373450 ENSP00000362549
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0001972 retinoic acid binding
GO:0004857 enzyme inhibitor activity
GO:0005496 steroid binding
GO:0005504 fatty acid binding
GO:0008144 drug binding
GO:0015020 glucuronosyltransferase activity
GO:0016758 transferase activity, transferring hexosyl groups
GO:0019899 enzyme binding
GO:0030246 carbohydrate binding
GO:0042803 protein homodimerization activity
GO:0046982 protein heterodimerization activity
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006631 fatty acid metabolic process
GO:0008152 metabolic process
GO:0008202 steroid metabolic process
GO:0009804 coumarin metabolic process
GO:0017144 drug metabolic process
GO:0030259 lipid glycosylation
GO:0031324 negative regulation of cellular metabolic process
GO:0042573 retinoic acid metabolic process
GO:0043086 negative regulation of catalytic activity
GO:0045922 negative regulation of fatty acid metabolic process
GO:0045939 negative regulation of steroid metabolic process
GO:0051552 flavone metabolic process
GO:0052696 flavonoid glucuronidation
GO:0052697 xenobiotic glucuronidation
GO:2001030 negative regulation of cellular glucuronidation
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016021 integral component of membrane
GO:0043231 intracellular membrane-bounded organelle
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
Glucuronidation pathway
Phase II conjugation pathway
Metabolism pathway
Biological oxidations pathway
KEGG
Pentose and glucuronate interconversions pathway
Ascorbate and aldarate metabolism pathway
Steroid hormone biosynthesis pathway
Starch and sucrose metabolism pathway
Retinol metabolism pathway
Porphyrin and chlorophyll metabolism pathway
Metabolism of xenobiotics by cytochrome P450 pathway
Drug metabolism pathway
Drug metabolism pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q9HAW9
TrEMBL Q5DSZ6
UniProt Splice Variant
Entrez Gene 54576
UniGene Hs.643992
RefSeq NM_019076
HUGO HGNC:12530
OMIM 191740 606433
CCDS CCDS33402
HPRD
IMGT
EMBL AC006985 AC019072 AF030310 AF297093 AF462267 AF462268 AF465198 AF465199 AF465200 AK313488 AY435143 CH471063 DQ364251
GenPept AAB84259 AAG30416 AAL73506 AAL73507 AAL73508 AAL75963 AAL75964 AAR95644 ABC96775 BAG36270 EAW71057
RNA Seq Atlas 54576