InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: UGT1A8

Summary

InnateDB Gene

IDBG-409444.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

UGT1A8

Gene Name

UDP glucuronosyltransferase 1 family, polypeptide A8

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000242366

Encoded Proteins

IDBP-83538

UDP glucuronosyltransferase 1 family, polypeptide A8

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene has glucuronidase activity with many substrates including coumarins, phenols, anthraquinones, flavones, and some opioids. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:233617645-233773310

Strand

Forward strand

Band

q37.1

Transcripts

ENST00000373450

ENSP00000362549

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001972	retinoic acid binding
GO:0004857	enzyme inhibitor activity
GO:0005496	steroid binding
GO:0005504	fatty acid binding
GO:0008144	drug binding
GO:0015020	glucuronosyltransferase activity
GO:0016758	transferase activity, transferring hexosyl groups
GO:0019899	enzyme binding
GO:0030246	carbohydrate binding
GO:0042803	protein homodimerization activity
GO:0046982	protein heterodimerization activity

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0006631	fatty acid metabolic process
GO:0008152	metabolic process
GO:0008202	steroid metabolic process
GO:0009804	coumarin metabolic process
GO:0017144	drug metabolic process
GO:0030259	lipid glycosylation
GO:0031324	negative regulation of cellular metabolic process
GO:0042573	retinoic acid metabolic process
GO:0043086	negative regulation of catalytic activity
GO:0045922	negative regulation of fatty acid metabolic process
GO:0045939	negative regulation of steroid metabolic process
GO:0051552	flavone metabolic process
GO:0052696	flavonoid glucuronidation
GO:0052697	xenobiotic glucuronidation
GO:2001030	negative regulation of cellular glucuronidation

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0016021	integral component of membrane
GO:0043231	intracellular membrane-bounded organelle

Orthologs

No orthologs found for this gene

Pathways

NETPATH

REACTOME

REACT_6784

Glucuronidation pathway

REACT_6959

Phase II conjugation pathway

REACT_111217

Metabolism pathway

REACT_13433

Biological oxidations pathway

KEGG

hsa00830

Retinol metabolism pathway

hsa00040

Pentose and glucuronate interconversions pathway

hsa00500

Starch and sucrose metabolism pathway

hsa00140

Steroid hormone biosynthesis pathway

hsa00053

Ascorbate and aldarate metabolism pathway

hsa00980

Metabolism of xenobiotics by cytochrome P450 pathway

hsa00860

Porphyrin and chlorophyll metabolism pathway

hsa00982

Drug metabolism pathway

hsa00983

Drug metabolism pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.643992

RefSeq

NM_019076

HUGO

OMIM

CCDS

CCDS33402

HPRD

07072

IMGT

EMBL

GenPept

RNA Seq Atlas