InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: UGT1A8

Summary

InnateDB Protein

IDBP-83538.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

UGT1A8

Protein Name

UDP glucuronosyltransferase 1 family, polypeptide A8

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000362549

InnateDB Gene

IDBG-409444 (UGT1A8)

Protein Structure

UniProt Annotation

Function

UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Isoform 2 lacks transferase activity but acts as a negative regulator of isoform 1. {ECO:0000269PubMed:19545173}.

Subcellular Localization

Microsome. Endoplasmic reticulum membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Colon specific. Isoform 1 and 2 are expressed in liver, kidney, colon and small intestine; isoform 2 but not isoform 1 is expressed in liver (PubMed:18004212). {ECO:0000269PubMed:18004212, ECO:0000269PubMed:9535849}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001972	retinoic acid binding
GO:0004857	enzyme inhibitor activity
GO:0005496	steroid binding
GO:0005504	fatty acid binding
GO:0008144	drug binding
GO:0015020	glucuronosyltransferase activity
GO:0016758	transferase activity, transferring hexosyl groups
GO:0019899	enzyme binding
GO:0030246	carbohydrate binding
GO:0042803	protein homodimerization activity
GO:0046982	protein heterodimerization activity

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0006631	fatty acid metabolic process
GO:0008152	metabolic process
GO:0008202	steroid metabolic process
GO:0009804	coumarin metabolic process
GO:0017144	drug metabolic process
GO:0030259	lipid glycosylation
GO:0031324	negative regulation of cellular metabolic process
GO:0042573	retinoic acid metabolic process
GO:0043086	negative regulation of catalytic activity
GO:0045922	negative regulation of fatty acid metabolic process
GO:0045939	negative regulation of steroid metabolic process
GO:0051552	flavone metabolic process
GO:0052696	flavonoid glucuronidation
GO:0052697	xenobiotic glucuronidation
GO:2001030	negative regulation of cellular glucuronidation

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0016021	integral component of membrane
GO:0043231	intracellular membrane-bounded organelle