Homo sapiens Gene: KIR2DL3
Summary
InnateDB Gene IDBG-409456.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KIR2DL3
Gene Name killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3
Synonyms CD158b; CD158B2; GL183; KIR-023GB; KIR-K7b; KIR-K7c; KIR2DS5; KIRCL23; NKAT; NKAT2; NKAT2A; NKAT2B; p58;
Species Homo sapiens
Ensembl Gene ENSG00000243772
Encoded Proteins
killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3
killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. [provided by RefSeq, Jul 2008]
Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:54724459-54767884
Strand Forward strand
Band q13.42
Transcripts
ENST00000342376 ENSP00000342215
ENST00000434419 ENSP00000415758
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
Experimentally validated
Total 12 [view]
Protein-Protein 9 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003823 antigen binding
GO:0004872 receptor activity
GO:0005515 protein binding
Biological Process
GO:0006955 immune response
GO:0050776 regulation of immune response
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016021 integral component of membrane
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell pathway
Adaptive Immune System pathway
Immune System pathway
KEGG
Antigen processing and presentation pathway
Natural killer cell mediated cytotoxicity pathway
Graft-versus-host disease pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt P43628
TrEMBL C6EVR7 E3NZD8 M4N692 M4NBK9 Q9UPI8
UniProt Splice Variant
Entrez Gene 3804
UniGene Hs.731378
RefSeq NM_015868
HUGO HGNC:6331
OMIM 604938
CCDS CCDS33107
HPRD 10383
IMGT
EMBL AC006293 AF022048 AH006692 AH007572 BC032422 BC050730 EU791543 FJ188693 KC261287 KC261292 KC261293 KC261294 KC261295 KC261296 L41268 L76662 L76663 U24074 U73395
GenPept AAA69869 AAB36590 AAB36591 AAB95321 AAC50333 AAC51147 AAC51651 AAD03160 AAD24477 AAH32422 AAH50730 ACI49714 ADN34702 AGG79413 AGG79418 AGG79419 AGG79421 AGG79422 AGG79423 AGG79424
RNA Seq Atlas 3804