Version 5.4
Homo sapiens Protein: KIR2DL3
Summary
InnateDB Protein IDBP-68937.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KIR2DL3
Protein Name killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3
Synonyms CD158b; CD158B2; GL183; KIR-023GB; KIR-K7b; KIR-K7c; KIR2DS5; KIRCL23; NKAT; NKAT2; NKAT2A; NKAT2B; p58;
Species Homo sapiens
Ensembl Protein ENSP00000342215
InnateDB Gene IDBG-409456 (KIR2DL3)
Protein Structure
UniProt Annotation
Function Receptor on natural killer (NK) cells for HLA-C alleles (HLA-Cw1, HLA-Cw3 and HLA-Cw7). Inhibits the activity of NK cells thus preventing cell lysis.
Subcellular Localization Cell membrane; Single-pass type I membrane protein.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
Experimentally validated
Total 12 [view]
Protein-Protein 9 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003823 antigen binding
GO:0004872 receptor activity
GO:0005515 protein binding
GO:0030110 HLA-C specific inhibitory MHC class I receptor activity
Biological Process
GO:0006952 defense response
GO:0006955 immune response
GO:0050776 regulation of immune response
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR003599 Immunoglobulin subtype
IPR013151 Immunoglobulin
PFAM PF00047
PRINTS
PIRSF
SMART SM00409
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P43628
PhosphoSite PhosphoSite-P43628
TrEMBL Q9UPI8
UniProt Splice Variant
Entrez Gene 3804
UniGene Hs.731378
RefSeq NP_056952
HUGO HGNC:6331
OMIM 604938
CCDS CCDS33107
HPRD 10383
IMGT
EMBL AC006293 AF022048 AH006692 AH007572 BC032422 BC050730 EU791543 FJ188693 KC261287 KC261292 KC261293 KC261294 KC261295 KC261296 L41268 L76662 L76663 U24074 U73395
GenPept AAA69869 AAB36590 AAB36591 AAB95321 AAC50333 AAC51147 AAC51651 AAD03160 AAD24477 AAH32422 AAH50730 ACI49714 ADN34702 AGG79413 AGG79418 AGG79419 AGG79421 AGG79422 AGG79423 AGG79424

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca