InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: SPRY2

Summary

InnateDB Gene

IDBG-41306.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SPRY2

Gene Name

sprouty homolog 2 (Drosophila)

Synonyms

hSPRY2

Species

Homo sapiens

Ensembl Gene

ENSG00000136158

Encoded Proteins

IDBP-41308

sprouty homolog 2 (Drosophila)

IDBP-41310

sprouty homolog 2 (Drosophila)

IDBP-599723

sprouty homolog 2 (Drosophila)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a protein belonging to the sprouty family. The encoded protein contains a carboxyl-terminal cysteine-rich domain essential for the inhibitory activity on receptor tyrosine kinase signaling proteins and is required for growth factor stimulated translocation of the protein to membrane ruffles. In primary dermal endothelial cells this gene is transiently upregulated in response to fibroblast growth factor two. This protein is indirectly involved in the non-cell autonomous inhibitory effect on fibroblast growth factor two signaling. The protein interacts with Cas-Br-M (murine) ectropic retroviral transforming sequence, and can function as a bimodal regulator of epidermal growth factor receptor/mitogen-activated protein kinase signaling. This protein may play a role in alveoli branching during lung development as shown by a similar mouse protein. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 13:80335976-80340951

Strand

Reverse strand

Band

q31.1

Transcripts

ENST00000377104	ENSP00000366308
ENST00000377102	ENSP00000366306
ENST00000540649	ENSP00000439027

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 91 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	91 [view]
Protein-Protein	89 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0019901	protein kinase binding
GO:0030291	protein serine/threonine kinase inhibitor activity
GO:0043539	protein serine/threonine kinase activator activity

Biological Process

GO:0000132	establishment of mitotic spindle orientation
GO:0007173	epidermal growth factor receptor signaling pathway
GO:0007275	multicellular organismal development
GO:0007605	sensory perception of sound
GO:0008285	negative regulation of cell proliferation
GO:0008543	fibroblast growth factor receptor signaling pathway
GO:0009966	regulation of signal transduction
GO:0010628	positive regulation of gene expression
GO:0010801	negative regulation of peptidyl-threonine phosphorylation
GO:0030324	lung development
GO:0033138	positive regulation of peptidyl-serine phosphorylation
GO:0034261	negative regulation of Ras GTPase activity
GO:0040037	negative regulation of fibroblast growth factor receptor signaling pathway
GO:0042059	negative regulation of epidermal growth factor receptor signaling pathway
GO:0042472	inner ear morphogenesis
GO:0043066	negative regulation of apoptotic process
GO:0043407	negative regulation of MAP kinase activity
GO:0045165	cell fate commitment
GO:0046580	negative regulation of Ras protein signal transduction
GO:0048754	branching morphogenesis of an epithelial tube
GO:0051387	negative regulation of neurotrophin TRK receptor signaling pathway
GO:0051897	positive regulation of protein kinase B signaling
GO:0060425	lung morphogenesis
GO:0060437	lung growth
GO:0060449	bud elongation involved in lung branching
GO:0060541	respiratory system development
GO:0070373	negative regulation of ERK1 and ERK2 cascade
GO:0070374	positive regulation of ERK1 and ERK2 cascade
GO:0071902	positive regulation of protein serine/threonine kinase activity