Homo sapiens Gene: SPRY2
Summary
InnateDB Gene IDBG-41306.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SPRY2
Gene Name sprouty homolog 2 (Drosophila)
Synonyms hSPRY2;
Species Homo sapiens
Ensembl Gene ENSG00000136158
Encoded Proteins
sprouty homolog 2 (Drosophila)
sprouty homolog 2 (Drosophila)
sprouty homolog 2 (Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein belonging to the sprouty family. The encoded protein contains a carboxyl-terminal cysteine-rich domain essential for the inhibitory activity on receptor tyrosine kinase signaling proteins and is required for growth factor stimulated translocation of the protein to membrane ruffles. In primary dermal endothelial cells this gene is transiently upregulated in response to fibroblast growth factor two. This protein is indirectly involved in the non-cell autonomous inhibitory effect on fibroblast growth factor two signaling. The protein interacts with Cas-Br-M (murine) ectropic retroviral transforming sequence, and can function as a bimodal regulator of epidermal growth factor receptor/mitogen-activated protein kinase signaling. This protein may play a role in alveoli branching during lung development as shown by a similar mouse protein. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:80335976-80340951
Strand Reverse strand
Band q31.1
Transcripts
ENST00000377104 ENSP00000366308
ENST00000377102 ENSP00000366306
ENST00000540649 ENSP00000439027
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 91 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Experimentally validated
Total 91 [view]
Protein-Protein 89 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0019901 protein kinase binding
GO:0030291 protein serine/threonine kinase inhibitor activity
GO:0043539 protein serine/threonine kinase activator activity
Biological Process
GO:0000132 establishment of mitotic spindle orientation
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007275 multicellular organismal development
GO:0007605 sensory perception of sound
GO:0008285 negative regulation of cell proliferation
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0009966 regulation of signal transduction
GO:0010628 positive regulation of gene expression
GO:0010801 negative regulation of peptidyl-threonine phosphorylation
GO:0030324 lung development
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0034261 negative regulation of Ras GTPase activity
GO:0040037 negative regulation of fibroblast growth factor receptor signaling pathway
GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway
GO:0042472 inner ear morphogenesis
GO:0043066 negative regulation of apoptotic process
GO:0043407 negative regulation of MAP kinase activity
GO:0045165 cell fate commitment
GO:0046580 negative regulation of Ras protein signal transduction
GO:0048754 branching morphogenesis of an epithelial tube
GO:0051387 negative regulation of neurotrophin TRK receptor signaling pathway
GO:0051897 positive regulation of protein kinase B signaling
GO:0060425 lung morphogenesis
GO:0060437 lung growth
GO:0060449 bud elongation involved in lung branching
GO:0060541 respiratory system development
GO:0070373 negative regulation of ERK1 and ERK2 cascade
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0071902 positive regulation of protein serine/threonine kinase activity
Cellular Component
GO:0005829 cytosol
GO:0005874 microtubule
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0032587 ruffle membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
EGFR1 pathway
REACTOME
Signaling by FGFR in disease pathway
Signaling by EGFR in Cancer pathway
Signaling by EGFR pathway
Spry regulation of FGF signaling pathway
Signal Transduction pathway
EGFR downregulation pathway
Signaling by FGFR pathway
Negative regulation of FGFR signaling pathway
Disease pathway
KEGG
Jak-STAT signaling pathway pathway
INOH
PID BIOCARTA
Sprouty regulation of tyrosine kinase signals [Biocarta view]
PID NCI
Internalization of ErbB1
Signaling events mediated by PTP1B
FGF signaling pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.595238
RefSeq NM_005842 XM_005266217 XM_006719752
HUGO
OMIM
CCDS CCDS9463
HPRD 03916
IMGT
EMBL
GenPept
RNA Seq Atlas