InnateDB Protein
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IDBP-599723.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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SPRY2
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Protein Name
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sprouty homolog 2 (Drosophila)
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Synonyms
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hSPRY2;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000439027
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InnateDB Gene
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IDBG-41306 (SPRY2)
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Protein Structure
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Function |
May function as an antagonist of fibroblast growth factor (FGF) pathways and may negatively modulate respiratory organogenesis. {ECO:0000269PubMed:10887178}.
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Subcellular Localization |
Cytoplasm, cytoskeleton {ECO:0000269PubMed:10887178}. Cell projection, ruffle membrane {ECO:0000269PubMed:10887178}. Note=Associated with microtubules in unstimulated cells but is translocated to the membrane ruffles in cells stimulated ith EGF (epidermal growth factor).
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 91 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Experimentally validated |
Total |
91
[view]
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Protein-Protein |
89
[view]
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Protein-DNA |
2
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
9 [view]
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Molecular Function |
Accession |
GO Term |
GO:0005515
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protein binding
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GO:0019901
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protein kinase binding
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GO:0030291
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protein serine/threonine kinase inhibitor activity
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GO:0043539
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protein serine/threonine kinase activator activity
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Biological Process |
GO:0007173
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epidermal growth factor receptor signaling pathway
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GO:0007275
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multicellular organismal development
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GO:0008543
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fibroblast growth factor receptor signaling pathway
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GO:0009966
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regulation of signal transduction
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GO:0010628
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positive regulation of gene expression
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GO:0010801
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negative regulation of peptidyl-threonine phosphorylation
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GO:0033138
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positive regulation of peptidyl-serine phosphorylation
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GO:0042059
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negative regulation of epidermal growth factor receptor signaling pathway
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GO:0043066
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negative regulation of apoptotic process
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GO:0051897
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positive regulation of protein kinase B signaling
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GO:0070374
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positive regulation of ERK1 and ERK2 cascade
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GO:0071902
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positive regulation of protein serine/threonine kinase activity
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Cellular Component |
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PDB ID |
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InterPro |
IPR007875
Sprouty
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PFAM |
PF05210
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
O43597
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PhosphoSite |
PhosphoSite-O43597
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
10253
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UniGene |
Hs.595238
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RefSeq |
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HUGO |
HGNC:11270
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OMIM |
602466
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CCDS |
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HPRD |
03916
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IMGT |
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EMBL |
AF039843
AK313810
AL354668
AL713749
BC015745
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GenPept |
AAC04258
AAH15745
BAG36546
CAD28524
CAI14911
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