Homo sapiens Gene: PMAIP1
Summary
InnateDB Gene IDBG-4142.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PMAIP1
Gene Name phorbol-12-myristate-13-acetate-induced protein 1
Synonyms APR; NOXA;
Species Homo sapiens
Ensembl Gene ENSG00000141682
Encoded Proteins
phorbol-12-myristate-13-acetate-induced protein 1
phorbol-12-myristate-13-acetate-induced protein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMAIP1 is induced by the RIG-I/MDA5 axis during viral infection and activates apoptosis in macrophages, dendritic cells and primary lymphocytes.
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 18:59899948-59904306
Strand Forward strand
Band q21.32
Transcripts
ENST00000316660 ENSP00000326119
ENST00000269518 ENSP00000269518
ENST00000590596
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.
Experimentally validated
Total 27 [view]
Protein-Protein 20 [view]
Protein-DNA 7 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0001836 release of cytochrome c from mitochondria
GO:0006915 apoptotic process
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006974 cellular response to DNA damage stimulus
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage
GO:0009411 response to UV
GO:0010165 response to X-ray
GO:0010498 proteasomal protein catabolic process
GO:0010907 positive regulation of glucose metabolic process
GO:0010917 negative regulation of mitochondrial membrane potential
GO:0032461 positive regulation of protein oligomerization
GO:0042149 cellular response to glucose starvation
GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0043029 T cell homeostasis
GO:0043065 positive regulation of apoptotic process
GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043331 response to dsRNA
GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator
GO:0043525 positive regulation of neuron apoptotic process
GO:0045087 innate immune response (InnateDB)
GO:0046902 regulation of mitochondrial membrane permeability
GO:0048147 negative regulation of fibroblast proliferation
GO:0051607 defense response to virus
GO:0071456 cellular response to hypoxia
GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator
GO:0072593 reactive oxygen species metabolic process
GO:0090200 positive regulation of release of cytochrome c from mitochondria
GO:0097193 intrinsic apoptotic signaling pathway
GO:1900740 positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
GO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:2001244 positive regulation of intrinsic apoptotic signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0005829 cytosol
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
Activation of NOXA and translocation to mitochondria pathway
Apoptosis pathway
Activation of BH3-only proteins pathway
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members pathway
Intrinsic Pathway for Apoptosis pathway
KEGG
p53 signaling pathway pathway
INOH
PID BIOCARTA
PID NCI
Direct p53 effectors
Validated targets of C-MYC transcriptional activation
Validated transcriptional targets of TAp63 isoforms
Cross-References
SwissProt
TrEMBL Q8N589
UniProt Splice Variant
Entrez Gene 5366
UniGene Hs.622958 Hs.96
RefSeq NM_021127
HUGO HGNC:9108
OMIM 604959
CCDS CCDS11975
HPRD 12002
IMGT
EMBL AC107990 BC032663
GenPept AAH32663
RNA Seq Atlas 5366