InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PMAIP1

Summary

InnateDB Protein

IDBP-4144.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PMAIP1

Protein Name

phorbol-12-myristate-13-acetate-induced protein 1

Synonyms

APR; NOXA;

Species

Homo sapiens

Ensembl Protein

ENSP00000326119

InnateDB Gene

IDBG-4142 (PMAIP1)

Protein Structure

UniProt Annotation

Function

Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation of MCL1. Competes with BAK1 for binding to MCL1 and can displace BAK1 from its binding site on MCL1 (By similarity). Competes with BIM/BCL2L11 for binding to MCL1 and can displace BIM/BCL2L11 from its binding site on MCL1. {ECO:0000250, ECO:0000269PubMed:10807576, ECO:0000269PubMed:15694340, ECO:0000269PubMed:15705586, ECO:0000269PubMed:17374615, ECO:0000269PubMed:17389404}.

Subcellular Localization

Mitochondrion {ECO:0000269PubMed:15705586, ECO:0000269PubMed:17374615}.

Disease Associations

Tissue Specificity

Highly expressed in adult T-cell leukemia cell line.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.

Experimentally validated
Total	27 [view]
Protein-Protein	20 [view]
Protein-DNA	7 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0001836	release of cytochrome c from mitochondria
GO:0006915	apoptotic process
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006974	cellular response to DNA damage stimulus
GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage
GO:0009411	response to UV
GO:0010165	response to X-ray
GO:0010498	proteasomal protein catabolic process
GO:0010907	positive regulation of glucose metabolic process
GO:0010917	negative regulation of mitochondrial membrane potential
GO:0032461	positive regulation of protein oligomerization
GO:0042149	cellular response to glucose starvation
GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0043029	T cell homeostasis
GO:0043065	positive regulation of apoptotic process
GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043331	response to dsRNA
GO:0043517	positive regulation of DNA damage response, signal transduction by p53 class mediator
GO:0043525	positive regulation of neuron apoptotic process
GO:0045087	innate immune response (InnateDB)
GO:0046902	regulation of mitochondrial membrane permeability
GO:0048147	negative regulation of fibroblast proliferation
GO:0051607	defense response to virus
GO:0071456	cellular response to hypoxia
GO:0072332	intrinsic apoptotic signaling pathway by p53 class mediator
GO:0072593	reactive oxygen species metabolic process
GO:0090200	positive regulation of release of cytochrome c from mitochondria
GO:0097193	intrinsic apoptotic signaling pathway
GO:1900740	positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
GO:1902043	positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:2001244	positive regulation of intrinsic apoptotic signaling pathway