Version 5.4
Homo sapiens Gene: P4HA2
Summary
InnateDB Gene IDBG-41442.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol P4HA2
Gene Name prolyl 4-hydroxylase, alpha polypeptide II
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000072682
Encoded Proteins
IDBP-41444
prolyl 4-hydroxylase, alpha polypeptide II
IDBP-41446
prolyl 4-hydroxylase, alpha polypeptide II
IDBP-41448
prolyl 4-hydroxylase, alpha polypeptide II
IDBP-41450
prolyl 4-hydroxylase, alpha polypeptide II
IDBP-41452
prolyl 4-hydroxylase, alpha polypeptide II
IDBP-240112
prolyl 4-hydroxylase, alpha polypeptide II
IDBP-293111
prolyl 4-hydroxylase, alpha polypeptide II
IDBP-376184
prolyl 4-hydroxylase, alpha polypeptide II
IDBP-376186
prolyl 4-hydroxylase, alpha polypeptide II
IDBP-376188
prolyl 4-hydroxylase, alpha polypeptide II
IDBP-376192
prolyl 4-hydroxylase, alpha polypeptide II
IDBP-376193
prolyl 4-hydroxylase, alpha polypeptide II
IDBP-376195
prolyl 4-hydroxylase, alpha polypeptide II
IDBP-376196
prolyl 4-hydroxylase, alpha polypeptide II
IDBP-376197
prolyl 4-hydroxylase, alpha polypeptide II
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a component of prolyl 4-hydroxylase, a key enzyme in collagen synthesis composed of two identical alpha subunits and two beta subunits. The encoded protein is one of several different types of alpha subunits and provides the major part of the catalytic site of the active enzyme. In collagen and related proteins, prolyl 4-hydroxylase catalyzes the formation of 4-hydroxyproline that is essential to the proper three-dimensional folding of newly synthesized procollagen chains. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:132191838-132295315
Strand Reverse strand
Band q31.1
Transcripts
ENST00000379104 ENSP00000368398
ENST00000379100 ENSP00000368394
ENST00000166534 ENSP00000166534
ENST00000379086 ENSP00000368379
ENST00000360568 ENSP00000353772
ENST00000395164 ENSP00000378593
ENST00000401867 ENSP00000384999
ENST00000417528 ENSP00000389523
ENST00000431054 ENSP00000391257
ENST00000439698 ENSP00000405406
ENST00000453286 ENSP00000413542
ENST00000428369 ENSP00000396495
ENST00000418055 ENSP00000403883
ENST00000416053 ENSP00000394953
ENST00000428841 ENSP00000395956
ENST00000474628
ENST00000467587
ENST00000478055
ENST00000471826
ENST00000481636
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
Experimentally validated
Total 7 [view]
Protein-Protein 6 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004656 procollagen-proline 4-dioxygenase activity
GO:0005506 iron ion binding
GO:0005515 protein binding
GO:0009055 electron carrier activity
GO:0016491 oxidoreductase activity
GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
GO:0031418 L-ascorbic acid binding
Biological Process
GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline
GO:0019511 peptidyl-proline hydroxylation
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005788 endoplasmic reticulum lumen
GO:0016222 procollagen-proline 4-dioxygenase complex
GO:0043231 intracellular membrane-bounded organelle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000018906
View Gene Order
ENSBTAG00000001116
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa00330
Arginine and proline metabolism pathway
INOH
INOH website
Arginine Proline metabolism pathway
PID NCI
Cross-References
SwissProt
TrEMBL C9JFJ1
UniProt Splice Variant
Entrez Gene 8974
UniGene Hs.519568
RefSeq NM_001017973 NM_001017974 NM_001142598 NM_001142599 NM_004199 XM_005272116 XM_005272117 XM_005272118 XM_005272119 XM_006714728 XM_006714729 XM_006714730
HUGO HGNC:8547
OMIM 600608
CCDS CCDS34230 CCDS4151
HPRD 11862
IMGT
EMBL AC034220 AC063976
GenPept
RNA Seq Atlas 101927705 8974

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca