Bos taurus Gene: P4HA2
Summary
InnateDB Gene IDBG-644698.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol P4HA2
Gene Name prolyl 4-hydroxylase subunit alpha-2 isoform 2 precursor
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000001116
Encoded Proteins
prolyl 4-hydroxylase subunit alpha-2 isoform 2
prolyl 4-hydroxylase subunit alpha-2 isoform 2
prolyl 4-hydroxylase subunit alpha-2 isoform 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000072682:
This gene encodes a component of prolyl 4-hydroxylase, a key enzyme in collagen synthesis composed of two identical alpha subunits and two beta subunits. The encoded protein is one of several different types of alpha subunits and provides the major part of the catalytic site of the active enzyme. In collagen and related proteins, prolyl 4-hydroxylase catalyzes the formation of 4-hydroxyproline that is essential to the proper three-dimensional folding of newly synthesized procollagen chains. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:23480315-23513315
Strand Forward strand
Band
Transcripts
ENSBTAT00000064203 ENSBTAP00000056064
ENSBTAT00000001479 ENSBTAP00000001479
ENSBTAT00000001477 ENSBTAP00000001477
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004656 procollagen-proline 4-dioxygenase activity
GO:0005506 iron ion binding
GO:0005515 protein binding
GO:0016491 oxidoreductase activity
GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
GO:0031418 L-ascorbic acid binding
Biological Process
GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline
GO:0019511 peptidyl-proline hydroxylation
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0016222 procollagen-proline 4-dioxygenase complex
GO:0043231 intracellular membrane-bounded organelle
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
SSD Ortholog
Ortholog supports species divergence
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
Arginine and proline metabolism pathway
Arginine and proline metabolism pathway
INOH
Arginine Proline metabolism pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL F1MJQ4
UniProt Splice Variant
Entrez Gene 507327
UniGene Bt.4381
RefSeq NM_001034293 NM_001159409 XM_005209035 XM_005209036 XM_005209037 XM_005209038 XM_005209040
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02019700
GenPept
RNA Seq Atlas 507327
Transcript Frequencies
Tag Count based mRNA-Abundances across 87 different Tissues (TPM).

Based on Data from Bovine Gene Atlas

Tag Count based mRNA-Abundances across 87 different Tissues (TPM)

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